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<p>The kidney plays a crucial role in regulating the acid-base balance of the body. The development of kidney diseases is often accompanied by changes in the renal PH, protein, glucose, urea, and other metabolites. Chemical exchange saturation transfer (CEST) imaging is a new magnetic resonance imaging (MRI) technique based on the chemical exchange between solute and water protons. The potential of CEST imaging in renal metabolic imaging stems from its ability to provide image contrast based on specific molecular compositions at relevant millimolar physiological concentrations. In this article, we briefly introduce the fundamental principles of CEST imaging and its applications in various renal disorders, including acute kidney injury, chronic kidney disease, renal tumors, and renal allograft rejection. Finally, we discuss the challenges and prospects of CEST imaging in the field of kidney diseases.</p> Graphical abstract <p></p>

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Chemical exchange saturation transfer magnetic resonance imaging of the kidney: applications and challenges

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月31日

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  • Lu Liu,
  • Songlin Guo,
  • Zhaoyu Xing,
  • Xingtian Yu,
  • Wenxia Mi,
  • Jiule Ding,
  • Jie Chen,
  • Wei Xing,
  • Liang Pan

摘要

The kidney plays a crucial role in regulating the acid-base balance of the body. The development of kidney diseases is often accompanied by changes in the renal PH, protein, glucose, urea, and other metabolites. Chemical exchange saturation transfer (CEST) imaging is a new magnetic resonance imaging (MRI) technique based on the chemical exchange between solute and water protons. The potential of CEST imaging in renal metabolic imaging stems from its ability to provide image contrast based on specific molecular compositions at relevant millimolar physiological concentrations. In this article, we briefly introduce the fundamental principles of CEST imaging and its applications in various renal disorders, including acute kidney injury, chronic kidney disease, renal tumors, and renal allograft rejection. Finally, we discuss the challenges and prospects of CEST imaging in the field of kidney diseases.

Graphical abstract