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Classification of intrahepatic cholangiocarcinoma

  • Maria El Homsi,
  • Ahmad Alkhasawneh,
  • Hina Arif-Tiwari,
  • Ferenc Czeyda-Pommersheim,
  • Hala Khasawneh,
  • Andrea Siobhan Kierans,
  • Raj Mohan Paspulati,
  • Charanjeet Singh

摘要

Cholangiocarcinoma is a heterogenous malignancy with various classifications based on location, morphological features, histological features, and actionable genetic mutations. Intrahepatic cholangiocarcinoma (ICC), which arises in and proximal to second order bile ducts, is the second most common primary liver malignancy after hepatocellular carcinoma. In this review, we will discuss ICC risk factors, precursor lesions, various growth, anatomic, morphologic, and histologic classifications, rare variants, and differential diagnoses.