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Purpose <p>Prospective multicenter trial to assess if testicular 18&#xa0;F-FDG uptake with PET/CT is correlated with the positivity rate of the surgical sperm extraction procedure (TESE), which has only a success rate of about 50%, in men with azoospermia.</p> Methods <p>Men with secretory azoospermia (SA), with excretory azoospermia (EA) and with normal spermogram (C) were included from february 2014 to may 2020. The baseline FDG PET/CT parameters that included peak, maximum and mean standardized uptake value and the functional testicular volume (FTV) were correlated with the TESE positivity and the standard clinical work up and the hormonal work up (FSH and inhibin and testosterone). A bivariate analysis was performed for the comparison between the two groups (positive or negative biopsy) and for the comparison between SA, EA and C with a significance level of 5%.</p> Results <p>The study included 84 SA, 26 EA and 25&#xa0;C. TESE was positive for 51 of the 97 men (53.13%). There was a significant correlation between the FTV and the positivity of TESE as well as with the FSH and inhibin and not with testosterone. The sum and the averaged FTV is significantly different between the three groups (SA, EA and C). FTV is significantly different from the testicular volume as determined via ultrasound (US) or CT. We found no significant correlation or difference for the intensity or the heterogeneity of FDG testicular uptake.</p> Conclusion <p>FTV obtained via PET/CT FDG is correlated with positivity of TESE in azoospermic men and is significantly different between the 3 groups ( EA, SA and C) and with the testicular volumes as obtained with US or CT. Furthermore, FTV is correlated with FSH and inhibin, which are parameters of the spermatogenesis and not with testosterone, a parameter of the steroidogenesis.</p>

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Is 18F-fluorodexyglucose testicular uptake using positron emission tomography/computed tomography correlated with the results of a testicular sperm extraction procedure in the case of azoospermia (French prospective multicenter AZOPREDHISTOTEP study)?

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Lawrence Oliver Dierickx,
  • Celia Bettiol,
  • Damien Huglo,
  • Francois Marcelli,
  • Louis Sibert,
  • Pierrick Gouel,
  • Ludovic Ferretti,
  • Fanny Orlhac,
  • Eric Huyghe

摘要

Purpose

Prospective multicenter trial to assess if testicular 18 F-FDG uptake with PET/CT is correlated with the positivity rate of the surgical sperm extraction procedure (TESE), which has only a success rate of about 50%, in men with azoospermia.

Methods

Men with secretory azoospermia (SA), with excretory azoospermia (EA) and with normal spermogram (C) were included from february 2014 to may 2020. The baseline FDG PET/CT parameters that included peak, maximum and mean standardized uptake value and the functional testicular volume (FTV) were correlated with the TESE positivity and the standard clinical work up and the hormonal work up (FSH and inhibin and testosterone). A bivariate analysis was performed for the comparison between the two groups (positive or negative biopsy) and for the comparison between SA, EA and C with a significance level of 5%.

Results

The study included 84 SA, 26 EA and 25 C. TESE was positive for 51 of the 97 men (53.13%). There was a significant correlation between the FTV and the positivity of TESE as well as with the FSH and inhibin and not with testosterone. The sum and the averaged FTV is significantly different between the three groups (SA, EA and C). FTV is significantly different from the testicular volume as determined via ultrasound (US) or CT. We found no significant correlation or difference for the intensity or the heterogeneity of FDG testicular uptake.

Conclusion

FTV obtained via PET/CT FDG is correlated with positivity of TESE in azoospermic men and is significantly different between the 3 groups ( EA, SA and C) and with the testicular volumes as obtained with US or CT. Furthermore, FTV is correlated with FSH and inhibin, which are parameters of the spermatogenesis and not with testosterone, a parameter of the steroidogenesis.