Scholarlink

Introduction <p>Cryptogenic stroke represents a third of ischemic strokes and has a significant recurrence rate. Occult cancer has been Identified as a causal factor in up to 5–10% of this type of strokes. We propose that a whole body FDG-PET/CT may increase the detection rate of occult cancer diagnosis in patients with cryptogenic stroke.</p> Patients and methods <p>Observational prospective study including patients with cryptogenic ischemic stroke who underwent an FDG-PET/CT scan. Clinical, radiological (three territory sign) and specific analytical measurements (D-dimer) were also informed.</p> Results <p>A total of 140 patients were included in the study, with a mean age of 71. The PET scan showed abnormalities in 30% of patients with cryptogenic stroke, with a confirmed cancer diagnosis in 18%. Elevated D-dimer levels and a higher OCCULT-5 score were associated with occult cancer.</p> Conclusions <p>Occult cancer was found in 18% of cryptogenic stroke cases in our study, evidenced by whole body FDF-PET/CT scans, which results in significant therapeutic and prognostic implications. Some imaging and analytical determinations seem to have potential for the selection of eligible patients for more advanced examinations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Detection rate of FDG-PET/CT for occult cancer in patients with cryptogenic ischemic stroke

  • 期刊论文

  • 发表日期：

    2025年9月13日

查看全文
  • Carmen García-Cabo,
  • Lorena Benavente,
  • Beatriz del Amor,
  • Carmen Vigil,
  • Sara Naranjo Sancho,
  • María Rico,
  • Montserrat González,
  • Davinia Larrosa,
  • María Castañón,
  • Elena López-Cancio,
  • Gemma González Velasco,
  • Sergio Calleja

摘要

Introduction

Cryptogenic stroke represents a third of ischemic strokes and has a significant recurrence rate. Occult cancer has been Identified as a causal factor in up to 5–10% of this type of strokes. We propose that a whole body FDG-PET/CT may increase the detection rate of occult cancer diagnosis in patients with cryptogenic stroke.

Patients and methods

Observational prospective study including patients with cryptogenic ischemic stroke who underwent an FDG-PET/CT scan. Clinical, radiological (three territory sign) and specific analytical measurements (D-dimer) were also informed.

Results

A total of 140 patients were included in the study, with a mean age of 71. The PET scan showed abnormalities in 30% of patients with cryptogenic stroke, with a confirmed cancer diagnosis in 18%. Elevated D-dimer levels and a higher OCCULT-5 score were associated with occult cancer.

Conclusions

Occult cancer was found in 18% of cryptogenic stroke cases in our study, evidenced by whole body FDF-PET/CT scans, which results in significant therapeutic and prognostic implications. Some imaging and analytical determinations seem to have potential for the selection of eligible patients for more advanced examinations.