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Purpose <p>This study aims to evaluate the performance of artificial intelligence (AI)-assisted PET imaging in predicting neoadjuvant chemotherapy (NAC) response in breast cancer patients.</p> Methods <p>The Ovid MEDLINE, Ovid Embase, Cochrane, Web of Science, and IEEE Xplore databases were systematically searched for studies utilizing AI algorithms in PET imaging for predicting responses to NAC in breast cancer, covering publications up to June 26, 2025. Binary diagnostic accuracy data were extracted for meta-analysis, with the area under the curve (AUC) serving as the primary outcome. Subgroup analyses and meta-regression analyses were conducted to explore potential sources of heterogeneity.</p> Results <p>Eighteen studies were eligible for systematic review, and eleven studies that selected 907 patients were included in the meta-analysis, with a pooled AUC of 0.80 (95% confidence interval [CI]: 0.77–0.84). However, significant heterogeneity was observed among the studies, with a <i>I²</i> of 79.65% (95% CI: 74.69–84.60) for sensitivity and 86.62% (95% CI: 83.73–89.51) for specificity. Meta-regression analyses revealed that patient sample size and the integration of clinical data in the models were significant contributors to heterogeneity.</p> Conclusions <p>The use of AI in predicting treatment response to NAC in breast cancer based on PET imaging demonstrated promising accuracy and potential for clinical use. But its clinical implementation is challenged by methodological variability, small datasets, lack of external validation and limited interpretability. Future research should prioritize the improvement of dataset quality and the integration of explainable AI (XAI) to facilitate the broader adoption of AI in clinical practice.</p>

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Artificial intelligence-assisted PET imaging for predicting neoadjuvant chemotherapy response in breast cancer: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • Yuhan Chen,
  • Yuan Sun,
  • Yuanjie Chen,
  • Jucheng Zhang,
  • Hang Zhang,
  • Ke Liu,
  • La Dong,
  • Xiaohui Zhang,
  • Rui Zhou,
  • Jing Wang,
  • Yan Zhong,
  • Mei Tian,
  • Hong Zhang

摘要

Purpose

This study aims to evaluate the performance of artificial intelligence (AI)-assisted PET imaging in predicting neoadjuvant chemotherapy (NAC) response in breast cancer patients.

Methods

The Ovid MEDLINE, Ovid Embase, Cochrane, Web of Science, and IEEE Xplore databases were systematically searched for studies utilizing AI algorithms in PET imaging for predicting responses to NAC in breast cancer, covering publications up to June 26, 2025. Binary diagnostic accuracy data were extracted for meta-analysis, with the area under the curve (AUC) serving as the primary outcome. Subgroup analyses and meta-regression analyses were conducted to explore potential sources of heterogeneity.

Results

Eighteen studies were eligible for systematic review, and eleven studies that selected 907 patients were included in the meta-analysis, with a pooled AUC of 0.80 (95% confidence interval [CI]: 0.77–0.84). However, significant heterogeneity was observed among the studies, with a I² of 79.65% (95% CI: 74.69–84.60) for sensitivity and 86.62% (95% CI: 83.73–89.51) for specificity. Meta-regression analyses revealed that patient sample size and the integration of clinical data in the models were significant contributors to heterogeneity.

Conclusions

The use of AI in predicting treatment response to NAC in breast cancer based on PET imaging demonstrated promising accuracy and potential for clinical use. But its clinical implementation is challenged by methodological variability, small datasets, lack of external validation and limited interpretability. Future research should prioritize the improvement of dataset quality and the integration of explainable AI (XAI) to facilitate the broader adoption of AI in clinical practice.