Scholarlink

Purpose <p>To evaluate the diagnostic performance of <sup>18</sup>F-FDG PET/CT parameters for T-lymphoblastic lymphoma (T-LBL), with particular emphasis on the “vasculature cast” sign, for distinguishing T-LBL from other pediatric anterior mediastinal malignancies.</p> Methods <p>Pretreatment <sup>18</sup>F-FDG PET/CT scan of 60 patients (≤ 21 years) with anterior mediastinal tumors were retrospectively analyzed. Diagnostic performance of the imaging parameters was compared between T-LBL and nonT-LBL groups. Intra- and interobserver agreement for vasculature cast sign was assessed.</p> Results <p>The vasculature cast sign was present in 15/24 T-LBL cases, with high specificity (97.2%) and positive predictive value (93.8%) but moderate sensitivity (62.5%). Intra- and interobserver agreement were 0.91 and 0.83, respectively. T-LBL had significantly larger tumor dimension (Dmax), lower SUVmax of the tumor or the spleen, higher total or mediastinal tumor metabolic tumor volume with a threshold of 41% of SUVmax and more frequent aortic arch encasement compared to nonT-LBL. Multivariable logistic regression identified the vasculature cast sign (odds ratio [OR], 37.45, 95% CI: 1.83-767.64, <i>p</i> = 0.019), tumor SUVmax (OR, 0.82, 95% CI: 0.69–0.97, <i>p</i> = 0.023) and Dmax &gt; 6.85&#xa0;cm (OR, 16.67; 95% CI: 1.76-158.21, <i>p</i> = 0.014) as independent imaging markers for T-LBL. Model combining these parameters yielded an area under the curve of 0.943 (<i>p</i> &lt; 0.001), and a simplified scoring system was developed based on the three parameters, yielding the diagnostic rates of 0% (0/8), 14.3% (3/21), 40% (6/15), and 100% (15/15) for scores of 0, 1, 2, and 3, respectively.</p> Conclusion <p>The vasculature cast sign is a specific and reproducible PET/CT marker of T-LBL.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Vasculature cast sign on 18F-FDG PET/CT: a specific imaging marker for pediatric T-lymphoblastic lymphoma

  • 期刊论文

  • 发表日期：

    2025年7月30日

查看全文
  • Haoyu Zhang,
  • Chao Li,
  • Yuxuan Chen,
  • Yafu Yin,
  • Hongliang Fu,
  • Hui Wang,
  • Suyun Chen

摘要

Purpose

To evaluate the diagnostic performance of 18F-FDG PET/CT parameters for T-lymphoblastic lymphoma (T-LBL), with particular emphasis on the “vasculature cast” sign, for distinguishing T-LBL from other pediatric anterior mediastinal malignancies.

Methods

Pretreatment 18F-FDG PET/CT scan of 60 patients (≤ 21 years) with anterior mediastinal tumors were retrospectively analyzed. Diagnostic performance of the imaging parameters was compared between T-LBL and nonT-LBL groups. Intra- and interobserver agreement for vasculature cast sign was assessed.

Results

The vasculature cast sign was present in 15/24 T-LBL cases, with high specificity (97.2%) and positive predictive value (93.8%) but moderate sensitivity (62.5%). Intra- and interobserver agreement were 0.91 and 0.83, respectively. T-LBL had significantly larger tumor dimension (Dmax), lower SUVmax of the tumor or the spleen, higher total or mediastinal tumor metabolic tumor volume with a threshold of 41% of SUVmax and more frequent aortic arch encasement compared to nonT-LBL. Multivariable logistic regression identified the vasculature cast sign (odds ratio [OR], 37.45, 95% CI: 1.83-767.64, p = 0.019), tumor SUVmax (OR, 0.82, 95% CI: 0.69–0.97, p = 0.023) and Dmax > 6.85 cm (OR, 16.67; 95% CI: 1.76-158.21, p = 0.014) as independent imaging markers for T-LBL. Model combining these parameters yielded an area under the curve of 0.943 (p < 0.001), and a simplified scoring system was developed based on the three parameters, yielding the diagnostic rates of 0% (0/8), 14.3% (3/21), 40% (6/15), and 100% (15/15) for scores of 0, 1, 2, and 3, respectively.

Conclusion

The vasculature cast sign is a specific and reproducible PET/CT marker of T-LBL.