Scholarlink

Purpose <p>To overcome difficulties with regard to anatomic discrimination of intrapelvic tumors and non-specific intrapelvic uptake (i.e. excreted activity in the urinary bladder) by early acquisition of FAPI-PET in prone position.</p> Methods <p>15 patients with rectosigmoid (RSC) and squamous cell carcinoma of the anus (SCCA) underwent early-imaging <sup>68</sup>Ga-FAPI-46-PET/CT-scans in prone position 5.9 ± 1.3&#xa0;min after radiotracer injection. SUV and metric values for primary tumors, metastases, bladder and background tissues were measured. Tumor-to-background ratios (TBR) were calculated.</p> Results <p>Despite early acquisition, SUV was already high in tumors and metastases, leading to high TBR. A sufficient, on average at least 2.56 ± 0.66&#xa0;cm, spatial distance between tumor and bladder uptake was observed in all cases.</p> Conclusion <p>An early-imaging protocol in prone position with <sup>68</sup>Ga-FAPI-46-PET/CT presents a viable option for non-invasive staging of SCCA and RSC with high TBR and good spatial separation from the urinary bladder.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Early image acquisition 68Ga-FAPI-46-PET/CT in prone position is promising in the workup of rectosigmoid and anal carcinoma

  • 期刊论文

  • 发表日期：

    2025年7月16日

查看全文
  • D. Ufton,
  • J. Heilinger,
  • H. Weis,
  • T. Fischer,
  • K. Schomäcker,
  • C. Bruns,
  • G. Dieplinger,
  • H. Dapper,
  • E. Fokas,
  • C. Kobe,
  • A. Drzezga,
  • S. Ferdinandus,
  • K. S. Roth

摘要

Purpose

To overcome difficulties with regard to anatomic discrimination of intrapelvic tumors and non-specific intrapelvic uptake (i.e. excreted activity in the urinary bladder) by early acquisition of FAPI-PET in prone position.

Methods

15 patients with rectosigmoid (RSC) and squamous cell carcinoma of the anus (SCCA) underwent early-imaging 68Ga-FAPI-46-PET/CT-scans in prone position 5.9 ± 1.3 min after radiotracer injection. SUV and metric values for primary tumors, metastases, bladder and background tissues were measured. Tumor-to-background ratios (TBR) were calculated.

Results

Despite early acquisition, SUV was already high in tumors and metastases, leading to high TBR. A sufficient, on average at least 2.56 ± 0.66 cm, spatial distance between tumor and bladder uptake was observed in all cases.

Conclusion

An early-imaging protocol in prone position with 68Ga-FAPI-46-PET/CT presents a viable option for non-invasive staging of SCCA and RSC with high TBR and good spatial separation from the urinary bladder.