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Background <p>In [<sup>18</sup>F]F-PSMA-1007 PET imaging, focal bone uptake without morphological correlate (MC) on CT, is often classified as benign. In [<sup>68</sup>Ga]Ga-PSMA-11, intense focal uptake without MC in a classical location is considered suspicious. The prevalence of focal bone uptake with or without MC on [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT remains unclear.</p> Methods <p>This single-center, retrospective study included patients who underwent a [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT scan for initial staging or biochemical recurrence (BCR) of prostate cancer between 04/16 − 11/21, with written informed consent for use of clinical data and adequate follow-up. For each patient with focal PSMA accumulation in the bones, up to three of these lesions were scored based on PSMA-RADS 2.0 and a clinical interpretation of suspicion for malignancy including clinical information was provided. In addition, MC on CT were assessed. A composite reference standard including imaging and clinical follow-up data was used.</p> Results <p>Out of 824 patients, 323 met eligibility criteria, with 101 showing PSMA-positive bone lesions. 176 lesions were included, 25% of 61 in the staging cohort had no MC, of which 73% were malignant. In the BCR group, 52% of 115 lesions were without MC, of which 48% were malignant. The sensitivity/specificity reached with PSMA-RADS 2.0, and MC on CT was 100%/100%and 78%/36% for staging, and 83%/100% and 60%/72% for BCR, respectively.</p> Conclusion <p>Focal [<sup>68</sup>Ga]Ga-PSMA-11 positive lesions without MC on CT are frequent, especially on scans for BCR, with the majority being malignant. Considering PSMA-RADS 4 lesions on [<sup>68</sup>Ga]Ga-PSMA-11 on staging exams, significantly improves the accuracy. Incorporating clinical information and considering PSMA-RADS 3B can further improve the sensitivity for BCR scans.</p>

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Assessing the frequency and accuracy of morphologic changes of focal bone lesions on [68Ga]Ga-PSMA-11 PET/CT in prostate cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月17日

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  • Thibika Sivakumar,
  • Jakob Heimer,
  • Stephan Beintner-Skawran,
  • Urs J. Muehlematter,
  • Michael Messerli,
  • Noel Spielhofer,
  • Daniel Eberli,
  • Martin W. Huellner,
  • Irene A. Burger,
  • Alexander Maurer

摘要

Background

In [18F]F-PSMA-1007 PET imaging, focal bone uptake without morphological correlate (MC) on CT, is often classified as benign. In [68Ga]Ga-PSMA-11, intense focal uptake without MC in a classical location is considered suspicious. The prevalence of focal bone uptake with or without MC on [68Ga]Ga-PSMA-11 PET/CT remains unclear.

Methods

This single-center, retrospective study included patients who underwent a [68Ga]Ga-PSMA-11 PET/CT scan for initial staging or biochemical recurrence (BCR) of prostate cancer between 04/16 − 11/21, with written informed consent for use of clinical data and adequate follow-up. For each patient with focal PSMA accumulation in the bones, up to three of these lesions were scored based on PSMA-RADS 2.0 and a clinical interpretation of suspicion for malignancy including clinical information was provided. In addition, MC on CT were assessed. A composite reference standard including imaging and clinical follow-up data was used.

Results

Out of 824 patients, 323 met eligibility criteria, with 101 showing PSMA-positive bone lesions. 176 lesions were included, 25% of 61 in the staging cohort had no MC, of which 73% were malignant. In the BCR group, 52% of 115 lesions were without MC, of which 48% were malignant. The sensitivity/specificity reached with PSMA-RADS 2.0, and MC on CT was 100%/100%and 78%/36% for staging, and 83%/100% and 60%/72% for BCR, respectively.

Conclusion

Focal [68Ga]Ga-PSMA-11 positive lesions without MC on CT are frequent, especially on scans for BCR, with the majority being malignant. Considering PSMA-RADS 4 lesions on [68Ga]Ga-PSMA-11 on staging exams, significantly improves the accuracy. Incorporating clinical information and considering PSMA-RADS 3B can further improve the sensitivity for BCR scans.