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Purpose <p>Post-COVID-19 lung disease (PCLD) is a significant concern following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. PCLD encompasses persistent debilitating respiratory symptoms and radiological changes beyond the acute disease phase. It highlights the ongoing search to identify and manage lingering diseases. This prospective study utilizes F18-Fludeoxyglucose (FDG) PET/CT to identify residual inflammatory lung lesions in PCLD. Treatment response was assessed after anti-inflammatory and antifibrotic therapies.</p> Materials and methods <p>Thirty patients post-severe COVID-19 pneumonia enrolled. They underwent baseline <sup>18</sup>F-FDG PET/CT scans to unveil residual lung inflammation lesions on FDG and CT. They received antifibrotic (Pirfenidone) and anti-inflammatory (Methylprednisolone) drugs for 6–12 weeks. They were followed up for clinical, biochemical, and imaging treatment responses.</p> Results <p>Baseline <sup>18</sup>F-FDG PET/CT revealed ongoing lung inflammation in all PCLD (mean SUV<sub>max</sub>: 3.8 ± 2.3 and number of segments: 8±3 ). The mean CT severity score was 17.7 ± 3.4 with moderate (<i>n</i> = 16) or severe (<i>n</i> = 14) disease involvement. Mild, moderate, and severe <sup>18</sup>F-FDG PET/CT categories were noted in the 8, 14, and 8 patients, respectively. Following treatment, a PET scan showed a significant decrease in disease extent (segments) and severity (FDG uptake) and an improvement in disease grading on imaging (97% of patients). In PET concordance, there was a significant clinical and radiological improvement with a fall in inflammatory markers (<i>p</i> &lt; 0.005). Serum Ferritin and total leukocyte counts were significantly associated with PCLD severity on <sup>18</sup>F-FDG PET/CT(<i>p</i> &lt; 0.05).</p> Conclusion <p>This prospective study identifies and quantifies ongoing significant residual lung inflammation in PCLD on <sup>18</sup>F-FDG PET/CT. Anti-inflammatory and antifibrotic drug therapy led to clinical and radiological improvement. <sup>18</sup>F-FDG PET/CT as a non-invasive biomarker helped manage and follow up PCLD patients.</p> Clinical trial number <p>Not applicable.</p>

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Post-COVID-19 lung disease: utility of biochemical and imaging markers in uncovering residual lung inflammation and monitoring anti-inflammatory therapy, a prospective study

  • 期刊论文

  • 发表日期：

    2025年5月13日

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  • Yogita Khandelwal,
  • Manish Ora,
  • Bela Jain,
  • Manish Dixit,
  • Prakash Singh,
  • Ajmal Khan,
  • Alok Nath,
  • Vikas Agarwal,
  • Sanjay Gambhir

摘要

Purpose

Post-COVID-19 lung disease (PCLD) is a significant concern following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. PCLD encompasses persistent debilitating respiratory symptoms and radiological changes beyond the acute disease phase. It highlights the ongoing search to identify and manage lingering diseases. This prospective study utilizes F18-Fludeoxyglucose (FDG) PET/CT to identify residual inflammatory lung lesions in PCLD. Treatment response was assessed after anti-inflammatory and antifibrotic therapies.

Materials and methods

Thirty patients post-severe COVID-19 pneumonia enrolled. They underwent baseline 18F-FDG PET/CT scans to unveil residual lung inflammation lesions on FDG and CT. They received antifibrotic (Pirfenidone) and anti-inflammatory (Methylprednisolone) drugs for 6–12 weeks. They were followed up for clinical, biochemical, and imaging treatment responses.

Results

Baseline 18F-FDG PET/CT revealed ongoing lung inflammation in all PCLD (mean SUVmax: 3.8 ± 2.3 and number of segments: 8±3 ). The mean CT severity score was 17.7 ± 3.4 with moderate (n = 16) or severe (n = 14) disease involvement. Mild, moderate, and severe 18F-FDG PET/CT categories were noted in the 8, 14, and 8 patients, respectively. Following treatment, a PET scan showed a significant decrease in disease extent (segments) and severity (FDG uptake) and an improvement in disease grading on imaging (97% of patients). In PET concordance, there was a significant clinical and radiological improvement with a fall in inflammatory markers (p < 0.005). Serum Ferritin and total leukocyte counts were significantly associated with PCLD severity on 18F-FDG PET/CT(p < 0.05).

Conclusion

This prospective study identifies and quantifies ongoing significant residual lung inflammation in PCLD on 18F-FDG PET/CT. Anti-inflammatory and antifibrotic drug therapy led to clinical and radiological improvement. 18F-FDG PET/CT as a non-invasive biomarker helped manage and follow up PCLD patients.

Clinical trial number

Not applicable.