Scholarlink

Purpose <p>Sentinel lymph node biopsy (SLNB) helps stage melanoma. Pre-surgical single-photon emission computed tomography/computed tomography (SPECT/CT) visualizes draining lymph nodes, but intraoperative gamma probe detection only estimates SLN location. This study evaluates augmented reality (AR) for projecting pre-surgical SLN imaging onto patients to aid precise localization and extraction.</p> Methods <p>Molecular sieves (8&#xa0;mm) incubated in fluorine-18 simulated lymph nodes and were implanted in the head and neck region of cadavers. Positron emission tomography/magnetic resonance imaging (PET/MRI) replaced SPECT/CT due to institutional restriction on cadavers. Virtual PET/MRI renderings were projected using the HoloLens 2 and custom software. Five cadavers underwent surgeries with standard, AR, and AR with head movement compensation methods.</p> Results <p>AR achieved a mean surface localization error of 2.5±2.0&#xa0;mm (range, 0–8&#xa0;mm) and a depth error of 2.3±1.7&#xa0;mm (range, 1–7&#xa0;mm), both within PET voxel resolution. For more challenging level V nodes, the mean surface error slightly increased to 2.9&#xa0;mm. Compared to manual surface marking, which had an average error of 18.6±13.0&#xa0;mm (range, 6–62&#xa0;mm), the AR system significantly reduced errors both in the head-straight and rotated positions (<i>p</i> &lt;.001). Additionally, the AR system reduced the task completion time by 74% (35.1/47.4&#xa0;s), with an average time of 12.3&#xa0;s compared to 47.4&#xa0;s for manual methods.</p> Conclusion <p>The AR system demonstrated high accuracy and efficiency in SLN localization, integrating head-movement compensation and 3D visualization to improve precision and reduce operating room time.</p> Clinical trial number <p>Not applicable.</p> Graphic abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Localization of sentinel lymph nodes using augmented-reality system: a cadaveric feasibility study

  • 期刊论文

  • 发表日期：

    2025年3月24日

查看全文
  • Heying Duan,
  • Yue Yang,
  • Wally L. Niu,
  • David Anders,
  • Andrew M. Dreisbach,
  • Dawn Holley,
  • Benjamin L. Franc,
  • Steffi L. Perkins,
  • Christoph Leuze,
  • Bruce L. Daniel,
  • Fred M. Baik

摘要

Purpose

Sentinel lymph node biopsy (SLNB) helps stage melanoma. Pre-surgical single-photon emission computed tomography/computed tomography (SPECT/CT) visualizes draining lymph nodes, but intraoperative gamma probe detection only estimates SLN location. This study evaluates augmented reality (AR) for projecting pre-surgical SLN imaging onto patients to aid precise localization and extraction.

Methods

Molecular sieves (8 mm) incubated in fluorine-18 simulated lymph nodes and were implanted in the head and neck region of cadavers. Positron emission tomography/magnetic resonance imaging (PET/MRI) replaced SPECT/CT due to institutional restriction on cadavers. Virtual PET/MRI renderings were projected using the HoloLens 2 and custom software. Five cadavers underwent surgeries with standard, AR, and AR with head movement compensation methods.

Results

AR achieved a mean surface localization error of 2.5±2.0 mm (range, 0–8 mm) and a depth error of 2.3±1.7 mm (range, 1–7 mm), both within PET voxel resolution. For more challenging level V nodes, the mean surface error slightly increased to 2.9 mm. Compared to manual surface marking, which had an average error of 18.6±13.0 mm (range, 6–62 mm), the AR system significantly reduced errors both in the head-straight and rotated positions (p <.001). Additionally, the AR system reduced the task completion time by 74% (35.1/47.4 s), with an average time of 12.3 s compared to 47.4 s for manual methods.

Conclusion

The AR system demonstrated high accuracy and efficiency in SLN localization, integrating head-movement compensation and 3D visualization to improve precision and reduce operating room time.

Clinical trial number

Not applicable.

Graphic abstract