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Purpose <p>The positron range effect can impair PET image quality of Gallium-68 (<sup>68</sup>Ga). A positron range correction (PRC) can be applied to reduce this effect. In this study, the effect of&#xa0;a tissue-independent PRC for <sup>68</sup>Ga was investigated on patient data.</p> Methods <p>PET/CT data (40 patients: [<sup>68</sup>Ga]Ga-DOTATOC or [<sup>68</sup>Ga]Ga-PSMA) were reconstructed using Q.Clear reconstruction algorithm. Two reconstructions were performed per patient, Q.Clear with and without PRC. SUV<sub>max</sub> and contrast-to-noise ratio (CNR) values per lesion were compared between PRC and non-PRC images. Five experienced nuclear medicine physicians reviewed the images and chose the preferred reconstruction based on the image quality, lesion detectability, and diagnostic confidence.</p> Results <p>A total of 155 lesions were identified. The PRC resulted in statistically significant increase of the SUV<sub>max</sub> and CNR for soft tissue lesions (6.4%, p &lt; 0.001; 8.6%, p &lt; 0.001), bone lesions (14.6%, p &lt; 0.001; 12.5%, p &lt; 0.001), and lung lesions (3.6%, p = 0.010; 6.3%, p = 0.001). This effect was most prominent in small lesions (SUV<sub>max</sub>: 12.0%, p &lt; 0.001, and CNR: 13.0%, p &lt; 0.001). Similar or better image quality, lesion detectability, and diagnostic confidence was achieved in PRC images compared to the non-PRC images as those assessed by the expert readers.</p> Conclusions <p>A tissue-independent PRC increased the SUV<sub>max</sub> and CNR in soft tissue, bone, and lung lesions with a larger effect for the small lesions. Visual assessment demonstrated similar or better image quality, lesion detectability, and diagnostic confidence in PRC images compared to the non-PRC images.</p>

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Impact of tissue-independent positron range correction on [68Ga]Ga-DOTATOC and [68Ga]Ga-PSMA PET image reconstructions: a patient data study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月29日

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  • Prodromos Gavriilidis,
  • Felix M. Mottaghy,
  • Michel Koole,
  • Tineke van de Weijer,
  • Cristina Mitea,
  • Jochem A. J. van der Pol,
  • Thiemo J. A. van Nijnatten,
  • Floris P. Jansen,
  • Roel Wierts

摘要

Purpose

The positron range effect can impair PET image quality of Gallium-68 (68Ga). A positron range correction (PRC) can be applied to reduce this effect. In this study, the effect of a tissue-independent PRC for 68Ga was investigated on patient data.

Methods

PET/CT data (40 patients: [68Ga]Ga-DOTATOC or [68Ga]Ga-PSMA) were reconstructed using Q.Clear reconstruction algorithm. Two reconstructions were performed per patient, Q.Clear with and without PRC. SUVmax and contrast-to-noise ratio (CNR) values per lesion were compared between PRC and non-PRC images. Five experienced nuclear medicine physicians reviewed the images and chose the preferred reconstruction based on the image quality, lesion detectability, and diagnostic confidence.

Results

A total of 155 lesions were identified. The PRC resulted in statistically significant increase of the SUVmax and CNR for soft tissue lesions (6.4%, p < 0.001; 8.6%, p < 0.001), bone lesions (14.6%, p < 0.001; 12.5%, p < 0.001), and lung lesions (3.6%, p = 0.010; 6.3%, p = 0.001). This effect was most prominent in small lesions (SUVmax: 12.0%, p < 0.001, and CNR: 13.0%, p < 0.001). Similar or better image quality, lesion detectability, and diagnostic confidence was achieved in PRC images compared to the non-PRC images as those assessed by the expert readers.

Conclusions

A tissue-independent PRC increased the SUVmax and CNR in soft tissue, bone, and lung lesions with a larger effect for the small lesions. Visual assessment demonstrated similar or better image quality, lesion detectability, and diagnostic confidence in PRC images compared to the non-PRC images.