Amino acid PET vs. RANO MRI for prediction of overall survival in patients with recurrent high grade glioma under bevacizumab therapy

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2024年1月17日

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Artem Chaban,
Birgit Waschulzik,
Denise Bernhardt,
Claire Delbridge,
Friederike Schmidt-Graf,
Arthur Wagner,
Benedikt Wiestler,
Wolfgang Weber,
Igor Yakushev

摘要

Purpose

To summarize evidence on the comparative value of amino acid (AA) PET and conventional MRI for prediction of overall survival (OS) in patients with recurrent high grade glioma (rHGG) under bevacizumab therapy.

Methods

Medical databases were screened for studies with individual data on OS, follow-up MRI, and PET findings in the same patient. MRI images were assessed according to the RANO criteria. A receiver operating characteristic curve analysis was used to predict OS at 9 months.

Results

Five studies with a total of 72 patients were included. Median OS was significantly lower in the PET-positive than in the PET-negative group. PET findings predicted OS with a pooled sensitivity and specificity of 76% and 71%, respectively. Corresponding values for MRI were 32% and 82%. Area under the curve and sensitivity were significantly higher for PET than for MRI.

Conclusion

For monitoring of patients with rHGG under bevacizumab therapy, AA-PET should be preferred over RANO MRI.