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Rationale and objectives <p>Zero echo time (ZTE) is an advanced MRI technique providing CT-like images of mineralized tissues. This study evaluates the impact of deep learning (DL)–based reconstruction with chemical shift correction (DLCSC) on osseous depiction in ZTE MRI of the lumbar spine, compared to standard DL and non-DL reconstruction.</p> Methods <p>This retrospective, single-center study included 38 patients undergoing 3 T ZTE MRI of the lumbar spine. K-space data were reconstructed using three methods: non-DL, standard DL, and a prototype DLCSC algorithm. Quantitative image sharpness, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were analyzed using repeated-measures ANOVA. Two radiologists independently rated pathology-related criteria (<i>n</i> = 22) and bone depiction quality (<i>n</i> = 38) on a 4-point scale. Ordinal data were analyzed using the Friedman test, and inter-reader agreement was assessed with weighted Cohen’s kappa.</p> Results <p>DLCSC images yielded quantitatively sharper images compared to non-DL (<i>p</i> = 0.010) and standard DL (<i>p</i> &lt; 0.001). SNR and CNR were significantly higher in DLCSC and DL than in non-DL (<i>p</i> &lt; 0.001). In the qualitative assessment, mean scores for all criteria of pathologies and bone depiction quality improved significantly from non-DL and DL to DLCSC (<i>p</i> &lt; 0.001). There was no evidence of differences in classification of pathologies (<i>p</i> &gt; 0.05). Inter-reader agreement ranged from substantial to almost perfect (<i>κ</i> = 0.867–0.901).</p> Conclusion <p>DLCSC image reconstruction of ZTE MRI can improve bone depiction of the lumbar spine compared to standard DL and non-DL reconstruction.</p>

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Deep learning-based chemical shift-artifact correction of ZTE MRI for enhanced bone depiction of the lumbar spine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Carina Obermüller,
  • Ulf Bach,
  • Fabio Zecca,
  • Franziska Heidt,
  • Maelene Lohezic,
  • Sagar Mandava,
  • Jose de Arcos Rodriguez,
  • Florian Wiesinger,
  • Roman Guggenberger,
  • Egon Burian,
  • Jonas Kroschke,
  • Falko Ensle

摘要

Rationale and objectives

Zero echo time (ZTE) is an advanced MRI technique providing CT-like images of mineralized tissues. This study evaluates the impact of deep learning (DL)–based reconstruction with chemical shift correction (DLCSC) on osseous depiction in ZTE MRI of the lumbar spine, compared to standard DL and non-DL reconstruction.

Methods

This retrospective, single-center study included 38 patients undergoing 3 T ZTE MRI of the lumbar spine. K-space data were reconstructed using three methods: non-DL, standard DL, and a prototype DLCSC algorithm. Quantitative image sharpness, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were analyzed using repeated-measures ANOVA. Two radiologists independently rated pathology-related criteria (n = 22) and bone depiction quality (n = 38) on a 4-point scale. Ordinal data were analyzed using the Friedman test, and inter-reader agreement was assessed with weighted Cohen’s kappa.

Results

DLCSC images yielded quantitatively sharper images compared to non-DL (p = 0.010) and standard DL (p < 0.001). SNR and CNR were significantly higher in DLCSC and DL than in non-DL (p < 0.001). In the qualitative assessment, mean scores for all criteria of pathologies and bone depiction quality improved significantly from non-DL and DL to DLCSC (p < 0.001). There was no evidence of differences in classification of pathologies (p > 0.05). Inter-reader agreement ranged from substantial to almost perfect (κ = 0.867–0.901).

Conclusion

DLCSC image reconstruction of ZTE MRI can improve bone depiction of the lumbar spine compared to standard DL and non-DL reconstruction.