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Objective <p>To evaluate anaemia-related alterations in lumbar bone marrow using apparent diffusion coefficient (ADC), fat fraction (FF), and signal intensity ratio (SIO), and to assess relationships with haematologic markers.</p> Methods <p>Ninety-three patients with abdominal MRI and available haemoglobin (Hb), red cell distribution width–coefficient of variation (RDW-CV),&#xa0;red cell distribution width–standard deviation (RDW-SD), and quantitative MRI parameters&#xa0;were included.&#xa0;Patients were classified into four Hb-based groups. Group differences were assessed using Kruskal–Wallis and Dunn–Bonferroni tests. Spearman correlation, age- and BMI-adjusted partial correlations and intraclass correlation coefficients (ICCs) were computed.</p> Results <p>Hb showed a positive correlation with FF (rho = 0.386, <i>p</i> &lt; 0.001) and a negative correlation with ADC (rho =  − 0.467, <i>p</i> &lt; 0.001). RDW-CV correlated negatively with FF (rho =  − 0.341, <i>p</i> = 0.001) and positively with ADC (rho = 0.300, <i>p</i> = 0.004). RDW-SD showed a weak positive correlation with ADC (rho = 0.208, <i>p</i> = 0.045). After age adjustment, RDW-SD correlated with FF (partial rho =  − 0.350, <i>p</i> = 0.001). The initially borderline RDW-SD–ADC association became significant after age (partial rho = 0.279, <i>p</i> = 0.007) and BMI adjustment (partial rho = 0.219, <i>p</i> = 0.035). FF and ADC differed across groups (<i>p</i> &lt; 0.05). FF was lowest in Group 4 (all <i>p</i> &lt; 0.05). ADC was higher in Group 4 than in Groups 1 and 2 (<i>p</i> ≤ 0.001) and higher in Group 3 than Group 1 (<i>p</i> = 0.035). All ICC values exceeded 0.90.</p> Conclusion <p>Quantitative MRI parameters reflect anaemia-related lumbar bone marrow microstructural alterations.</p>

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MRI-based biomarkers of bone marrow adaptation in anemia: A quantitative evaluation

  • 期刊论文

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  • 发表日期：

    2026年5月18日

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  • Duygu Erkal,
  • Mehmet Tonkaz,
  • Serdar Aslan,
  • Gökhan Tonkaz

摘要

Objective

To evaluate anaemia-related alterations in lumbar bone marrow using apparent diffusion coefficient (ADC), fat fraction (FF), and signal intensity ratio (SIO), and to assess relationships with haematologic markers.

Methods

Ninety-three patients with abdominal MRI and available haemoglobin (Hb), red cell distribution width–coefficient of variation (RDW-CV), red cell distribution width–standard deviation (RDW-SD), and quantitative MRI parameters were included. Patients were classified into four Hb-based groups. Group differences were assessed using Kruskal–Wallis and Dunn–Bonferroni tests. Spearman correlation, age- and BMI-adjusted partial correlations and intraclass correlation coefficients (ICCs) were computed.

Results

Hb showed a positive correlation with FF (rho = 0.386, p < 0.001) and a negative correlation with ADC (rho =  − 0.467, p < 0.001). RDW-CV correlated negatively with FF (rho =  − 0.341, p = 0.001) and positively with ADC (rho = 0.300, p = 0.004). RDW-SD showed a weak positive correlation with ADC (rho = 0.208, p = 0.045). After age adjustment, RDW-SD correlated with FF (partial rho =  − 0.350, p = 0.001). The initially borderline RDW-SD–ADC association became significant after age (partial rho = 0.279, p = 0.007) and BMI adjustment (partial rho = 0.219, p = 0.035). FF and ADC differed across groups (p < 0.05). FF was lowest in Group 4 (all p < 0.05). ADC was higher in Group 4 than in Groups 1 and 2 (p ≤ 0.001) and higher in Group 3 than Group 1 (p = 0.035). All ICC values exceeded 0.90.

Conclusion

Quantitative MRI parameters reflect anaemia-related lumbar bone marrow microstructural alterations.