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Abstract <p>β-1,2-Glucans are physiologically important polymers for interactions such as symbiosis and pathogenesis between organisms and adaptation to environmental changes. However, rarity of β-1,2-glucans in nature limits exploration of related enzymes. Recently, many β-1,2-glucan-degrading enzymes have been found after identification of a novel phosphorylase acting on β-1,2-glucooligosaccharides. The expansion of the repertoire has reached revelation of&#xa0;the cyclization mechanism of cyclic β-1,2-glucan synthase and led to finding of new enzymes catalyzing cyclization of β-1,2-glucans in a manner different from cyclic β-1,2-glucan synthase. In this review, we mainly focus on newly found enzymes that catalyze cyclization of β-1,2-glucans along with existence of β-1,2-glucan-associated carbohydrates in nature and introduction of the repertoire of β-1,2-glucan-degrading enzymes.</p> Key points <p>• <i>Newly found domain which&#xa0;cyclizes β-1,2-glucan created a new glycoside hydrolase family.</i></p> <p>• <i>Cyclization is performed with a unique mechanism.</i></p> <p>• <i>α-1,6-Cyclized β-1,2-glucan is produced by an enzyme in another newly found family.</i></p>

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Enzymes that catalyze cyclization of β-1,2-glucans

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月20日

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  • Masahiro Nakajima,
  • Sei Motouchi,
  • Nobukiyo Tanaka,
  • Tomoko Masaike

摘要

Abstract

β-1,2-Glucans are physiologically important polymers for interactions such as symbiosis and pathogenesis between organisms and adaptation to environmental changes. However, rarity of β-1,2-glucans in nature limits exploration of related enzymes. Recently, many β-1,2-glucan-degrading enzymes have been found after identification of a novel phosphorylase acting on β-1,2-glucooligosaccharides. The expansion of the repertoire has reached revelation of the cyclization mechanism of cyclic β-1,2-glucan synthase and led to finding of new enzymes catalyzing cyclization of β-1,2-glucans in a manner different from cyclic β-1,2-glucan synthase. In this review, we mainly focus on newly found enzymes that catalyze cyclization of β-1,2-glucans along with existence of β-1,2-glucan-associated carbohydrates in nature and introduction of the repertoire of β-1,2-glucan-degrading enzymes.

Key points

• Newly found domain which cyclizes β-1,2-glucan created a new glycoside hydrolase family.

• Cyclization is performed with a unique mechanism.

• α-1,6-Cyclized β-1,2-glucan is produced by an enzyme in another newly found family.