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<p>We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.</p>

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The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in retinoblastoma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月18日

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  • Sonia De Francesco,
  • Paolo Galluzzi,
  • Tommaso Padula,
  • Giovanni Rubegni,
  • Pierluigi De Marzo,
  • Mario Fruschelli,
  • Doris Hadjistilianou

摘要

We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.