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Background <p>Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.</p> Objective <p>The purpose of this study was to&#xa0;examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl.</p> Materials and&#xa0;Methods <p>This retrospective study included children (&lt; 18&#xa0;years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample <i>t</i>-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.</p> Results <p>Among 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (<i>P</i> = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; <i>P</i> &lt; 0.001) and BMI (20.1 vs. 17.7; <i>P</i> &lt; 0.001) were significantly associated with brown fat uptake.</p> Conclusion <p>Fentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.</p> Graphical Abstract <p></p>

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Does the addition of fentanyl premedication impact brown fat uptake in children undergoing a warming protocol for FDG PET?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月4日

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  • Mariama Lukulay,
  • Pradipta Debnath,
  • Christopher G. Anton,
  • Yinan Li,
  • Adam F. Prasanphanich,
  • Susan E. Sharp,
  • Bin Zhang,
  • Andrew T. Trout,
  • Cara E. Morin

摘要

Background

Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.

Objective

The purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl.

Materials and Methods

This retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample t-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.

Results

Among 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (P = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; P < 0.001) and BMI (20.1 vs. 17.7; P < 0.001) were significantly associated with brown fat uptake.

Conclusion

Fentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.

Graphical Abstract