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Background <p>Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements.</p> Objective <p>To assess the consistency of 2-dimensional (D) biometric and 3-D volumetric measurements across three hospitals using three widely used super-resolution reconstruction pipelines.</p> Materials and methods <p>This retrospective multi-centric study used T2-weighted fetal brain MRI scans acquired at three hospitals between 2009 and 2023. MRIs from each subject were reconstructed with each super-resolution reconstruction method, and biometric measurements were performed by four experts. Automated 3-D volumetry was performed using a state-of-the-art segmentation method. A qualitative evaluation assessed the clinicians’ likelihood of using super-resolution reconstructed volumes in their practice.</p> Results <p>Eighty-four healthy subjects were included. Biometric measurements revealed statistically significant changes that consistently remained below voxel width (0.8&#xa0;mm; <i>P</i>&lt;0.001). Automated 3-D volumetry revealed small systematic effects (&lt;2.8%; <i>P</i>&lt;0.001). The qualitative evaluation showed systematic differences between super-resolution reconstruction methods for the perception of white matter intensity (<i>P</i>=0.02) and sharpness of the image (<i>P</i>=0.01).</p> Conclusion <p>Variations in 2-D and 3-D quantitative measurements did not show any large systematic bias when using different super-resolution reconstruction methods for clinical radiological assessment across centers, scanners, and raters.</p>

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Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月8日

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  • Thomas Sanchez,
  • Angeline Mihailov,
  • Mériam Koob,
  • Nadine Girard,
  • Aurélie Manchon,
  • Ignacio Valenzuela,
  • Marta Gómez-Chiari,
  • Gerard Martí Juan,
  • Alexandre Pron,
  • Elisenda Eixarch,
  • Gemma Piella,
  • Miguel Angel Gonzalez Ballester,
  • Oscar Camara,
  • Vincent Dunet,
  • Guillaume Auzias,
  • Meritxell Bach Cuadra

摘要

Background

Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements.

Objective

To assess the consistency of 2-dimensional (D) biometric and 3-D volumetric measurements across three hospitals using three widely used super-resolution reconstruction pipelines.

Materials and methods

This retrospective multi-centric study used T2-weighted fetal brain MRI scans acquired at three hospitals between 2009 and 2023. MRIs from each subject were reconstructed with each super-resolution reconstruction method, and biometric measurements were performed by four experts. Automated 3-D volumetry was performed using a state-of-the-art segmentation method. A qualitative evaluation assessed the clinicians’ likelihood of using super-resolution reconstructed volumes in their practice.

Results

Eighty-four healthy subjects were included. Biometric measurements revealed statistically significant changes that consistently remained below voxel width (0.8 mm; P<0.001). Automated 3-D volumetry revealed small systematic effects (<2.8%; P<0.001). The qualitative evaluation showed systematic differences between super-resolution reconstruction methods for the perception of white matter intensity (P=0.02) and sharpness of the image (P=0.01).

Conclusion

Variations in 2-D and 3-D quantitative measurements did not show any large systematic bias when using different super-resolution reconstruction methods for clinical radiological assessment across centers, scanners, and raters.