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Background <p>Monitoring intracranial pressure (ICP) is essential in pediatric neurocritical care, but invasive methods pose risks, highlighting the need for accurate non-invasive alternatives like ultrasonographic optic nerve sheath diameter (ONSD) measurement.</p> Objective <p>To evaluate the diagnostic accuracy of ultrasonographic measurement of the ONSD for detecting elevated ICP in children, stratified by age (&lt; 1&#xa0;year or &gt; 1&#xa0;year).</p> Materials and methods <p>A systematic search was conducted in PubMed, Embase, and Cochrane from inception to February 3, 2025. Eligible studies included prospective or retrospective cohorts and randomized trials comparing ultrasonographic ONSD with invasive ICP measurements (mmHg) in pediatric patients, reporting data for a 2 × 2 table. The analyses included (1) sensitivity; (2) specificity; (3) summary receiver operating characteristic curve; (4) area under the curve; (5) diagnostic odds ratio; and (6) likelihood ratios. A random-effects model was used, with 95% confidence intervals and subgroup differences assessed (<i>P</i> &lt; 0.05 statistically significant).</p> Results <p>Seven studies with 380 patients were included. ONSD cutoffs ranged from 4.0&#xa0;mm to 5.29&#xa0;mm across studies. For the 20&#xa0;mmHg cutoff (<i>n</i> = 369), sensitivity was 91.6% [95% CI, 83.2–96.0] and specificity was 71.9% [95% CI, 65.4–77.6]. For the 15&#xa0;mmHg cutoff (<i>n</i> = 304), sensitivity was 89.3% [95% CI, 83.9–93.1] and specificity was 76.2% [95% CI, 68.0–82.8]. Sensitivity differences by age were statistically significant at 20&#xa0;mmHg (<i>P</i> = 0.03), with 245 patients &gt; 1&#xa0;year (sensitivity, 90.1% [95% CI, 83.3–94.3]) and 124 patients &lt; 1&#xa0;year (sensitivity, 75.7% [95% CI, 59.5–86.8]).</p> Conclusion <p>The diagnostic accuracy of ultrasound-measured ONSD in detecting intracranial hypertension was high in pediatric patients, although sensitivity varied with age. These findings highlight the importance of age-stratified analyses to assess ONSD accuracy, particularly in infants.</p> Graphical Abstract <p></p>

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Diagnostic accuracy of ultrasonographic optic nerve sheath diameter compared to invasive ICP monitoring for intracranial hypertension in pediatric patients

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • João Paulo Liute Scarramal,
  • Eric Slawka,
  • Luiza Giuliani Schmitt,
  • Victor Arthur Ohannesian,
  • Pedro Borges,
  • Stefeson Gomes Cabral Junior,
  • Igor Menezes Rocha,
  • Vida Castella,
  • Fellipe Feijó Halfeld,
  • Helvécio Neves Feitosa Filho,
  • Heitor Medeiros,
  • Raphael Bertani,
  • Marcio Yuri Ferreira,
  • Christian Ferreira

摘要

Background

Monitoring intracranial pressure (ICP) is essential in pediatric neurocritical care, but invasive methods pose risks, highlighting the need for accurate non-invasive alternatives like ultrasonographic optic nerve sheath diameter (ONSD) measurement.

Objective

To evaluate the diagnostic accuracy of ultrasonographic measurement of the ONSD for detecting elevated ICP in children, stratified by age (< 1 year or > 1 year).

Materials and methods

A systematic search was conducted in PubMed, Embase, and Cochrane from inception to February 3, 2025. Eligible studies included prospective or retrospective cohorts and randomized trials comparing ultrasonographic ONSD with invasive ICP measurements (mmHg) in pediatric patients, reporting data for a 2 × 2 table. The analyses included (1) sensitivity; (2) specificity; (3) summary receiver operating characteristic curve; (4) area under the curve; (5) diagnostic odds ratio; and (6) likelihood ratios. A random-effects model was used, with 95% confidence intervals and subgroup differences assessed (P < 0.05 statistically significant).

Results

Seven studies with 380 patients were included. ONSD cutoffs ranged from 4.0 mm to 5.29 mm across studies. For the 20 mmHg cutoff (n = 369), sensitivity was 91.6% [95% CI, 83.2–96.0] and specificity was 71.9% [95% CI, 65.4–77.6]. For the 15 mmHg cutoff (n = 304), sensitivity was 89.3% [95% CI, 83.9–93.1] and specificity was 76.2% [95% CI, 68.0–82.8]. Sensitivity differences by age were statistically significant at 20 mmHg (P = 0.03), with 245 patients > 1 year (sensitivity, 90.1% [95% CI, 83.3–94.3]) and 124 patients < 1 year (sensitivity, 75.7% [95% CI, 59.5–86.8]).

Conclusion

The diagnostic accuracy of ultrasound-measured ONSD in detecting intracranial hypertension was high in pediatric patients, although sensitivity varied with age. These findings highlight the importance of age-stratified analyses to assess ONSD accuracy, particularly in infants.

Graphical Abstract