Scholarlink

<p>Understanding relationships between specific measures of adiposity and heart rate variability (HRV) allows for better understanding obesity as a risk factor for cardiovascular and autonomic dysfunction. We sought to examine associations between specific adiposity depots and cardiovascular autonomic function assessed via HRV among children and adolescents. We performed a secondary cross-sectional analysis of a previously completed study of 8–17-year-olds (n = 325; 12.4 ± 2.7&#xa0;years). Adiposity was assessed via dual x-ray absorptiometry. Resting HRV measures included root mean square of successive differences (RMSSD), percentage of successive normal-to-normal intervals differing by more than 50&#xa0;ms (pNN50), low frequency power (LF), high frequency power (HF), and low frequency-to-high frequency ratio (LF:HF). Associations between adiposity and HRV were evaluated using linear regression modeling, adjusting for sex and Tanner stage. RMSSD and pNN50 were both negatively associated with total fat (β = −&#xa0;0.558, <i>p</i> = 0.004; β = −&#xa0;0.178, <i>p</i> = 0.034), percent body fat (β = −&#xa0;0.790, <i>p</i> = 0.007; β = −&#xa0;0.296, <i>p</i> = 0.019), trunk fat (β = −&#xa0;1.024, <i>p</i> = 0.004; β = −&#xa0;0.344, <i>p</i> = 0.022), android fat (β = −&#xa0;0.005, <i>p</i> = 0.006; β = −&#xa0;0.002, <i>p</i> = 0.028), gynoid fat (β = −&#xa0;0.003, <i>p</i> = 0.005; β = −&#xa0;0.001, <i>p</i> = 0.034), visceral adipose tissue (β = −&#xa0;0.013, <i>p</i> = 0.016; β = −&#xa0;0.005, <i>p</i> = 0.038) and subcutaneous abdominal adipose tissue (β = −&#xa0;0.007, <i>p</i> = 0.004; β = −&#xa0;0.003, <i>p</i> = 0.017). RMSSD was negatively associated with appendicular fat (β = −&#xa0;1.152,<i> p</i> = 0.008). Visceral adipose tissue was associated positively with LF and LF: HF (β = 0.004, <i>p</i> = 0.028; β = 0.019, <i>p</i> = 0.033) and negatively with HF (β = −&#xa0;0.004, <i>p</i> = 0.028). We found that excess total and regional adiposity may have negative effects on cardiovascular autonomic nervous system function in a large cohort of children and adolescents. Longitudinal studies are needed to confirm and determine how these relationships change over time<b>.</b></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Relationships Between Adiposity Measures and Heart Rate Variability in Children and Adolescents

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月10日

查看全文
  • William T. Juckett,
  • Nicholas G. Evanoff,
  • Aaron S. Kelly,
  • Eric M. Bomberg,
  • Donald R. Dengel

摘要

Understanding relationships between specific measures of adiposity and heart rate variability (HRV) allows for better understanding obesity as a risk factor for cardiovascular and autonomic dysfunction. We sought to examine associations between specific adiposity depots and cardiovascular autonomic function assessed via HRV among children and adolescents. We performed a secondary cross-sectional analysis of a previously completed study of 8–17-year-olds (n = 325; 12.4 ± 2.7 years). Adiposity was assessed via dual x-ray absorptiometry. Resting HRV measures included root mean square of successive differences (RMSSD), percentage of successive normal-to-normal intervals differing by more than 50 ms (pNN50), low frequency power (LF), high frequency power (HF), and low frequency-to-high frequency ratio (LF:HF). Associations between adiposity and HRV were evaluated using linear regression modeling, adjusting for sex and Tanner stage. RMSSD and pNN50 were both negatively associated with total fat (β = − 0.558, p = 0.004; β = − 0.178, p = 0.034), percent body fat (β = − 0.790, p = 0.007; β = − 0.296, p = 0.019), trunk fat (β = − 1.024, p = 0.004; β = − 0.344, p = 0.022), android fat (β = − 0.005, p = 0.006; β = − 0.002, p = 0.028), gynoid fat (β = − 0.003, p = 0.005; β = − 0.001, p = 0.034), visceral adipose tissue (β = − 0.013, p = 0.016; β = − 0.005, p = 0.038) and subcutaneous abdominal adipose tissue (β = − 0.007, p = 0.004; β = − 0.003, p = 0.017). RMSSD was negatively associated with appendicular fat (β = − 1.152, p = 0.008). Visceral adipose tissue was associated positively with LF and LF: HF (β = 0.004, p = 0.028; β = 0.019, p = 0.033) and negatively with HF (β = − 0.004, p = 0.028). We found that excess total and regional adiposity may have negative effects on cardiovascular autonomic nervous system function in a large cohort of children and adolescents. Longitudinal studies are needed to confirm and determine how these relationships change over time.