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<p>Stones can form anywhere in the urinary system but most commonly develop in the upper urinary tract, particularly the kidneys and ureters. In this study, we examined the relationship between ABO blood type and upper urinary tract stone formation in a region with high disease incidence. This retrospective case-control study included 1,000 patients diagnosed with upper urinary tract stones (kidney or ureter) and 1,000 randomly selected controls presenting to urology outpatient clinics between January 2022 and December 2024. Demographic characteristics, ABO blood groups, body mass index (BMI), and comorbidities were compared between groups. No significant differences in age (39.87 ± 16.75 vs. 41.60 ± 19.38 years, <i>p</i> = 0.160) or sex distribution (69.9% vs. 61.0% male, <i>p</i> = 0.087) were observed. Stone patients had significantly higher BMI (29.87 ± 12.43 vs. 27.24 ± 15.38&#xa0;kg/m², <i>p</i> = 0.003) and comorbidity rates (38.6% vs. 21.6%, <i>p</i> = 0.006). Blood groups A and O were more frequent in stone-formers than controls (43.2% vs. 37.6%, <i>p</i> = 0.008; and 33.6% vs. 25.5%, <i>p</i> = 0.001, respectively), whereas blood group B was less frequent (15.1% vs. 25.0%, <i>p</i> = 0.003). Multivariate analysis indicated that blood groups A (AOR = 2.43, 95% CI: 1.57–3.76, <i>p</i> &lt; 0.001) and O (AOR = 2.26, 95% CI: 1.42–3.59, <i>p</i> &lt; 0.001) were independent risk factors, while blood group B showed a protective effect (AOR = 0.61, 95% CI: 0.38–0.98, <i>p</i> = 0.041). These findings suggest that blood groups A and O blood groups may be associated with urolithiasis susceptibility in this population, though the underlying mechanisms require further investigation.</p>

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ABO blood group distribution in patients with upper urinary tract stones: a case–control study

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Emrullah Durmus,
  • Mehmet Sevim,
  • Fesih Ok

摘要

Stones can form anywhere in the urinary system but most commonly develop in the upper urinary tract, particularly the kidneys and ureters. In this study, we examined the relationship between ABO blood type and upper urinary tract stone formation in a region with high disease incidence. This retrospective case-control study included 1,000 patients diagnosed with upper urinary tract stones (kidney or ureter) and 1,000 randomly selected controls presenting to urology outpatient clinics between January 2022 and December 2024. Demographic characteristics, ABO blood groups, body mass index (BMI), and comorbidities were compared between groups. No significant differences in age (39.87 ± 16.75 vs. 41.60 ± 19.38 years, p = 0.160) or sex distribution (69.9% vs. 61.0% male, p = 0.087) were observed. Stone patients had significantly higher BMI (29.87 ± 12.43 vs. 27.24 ± 15.38 kg/m², p = 0.003) and comorbidity rates (38.6% vs. 21.6%, p = 0.006). Blood groups A and O were more frequent in stone-formers than controls (43.2% vs. 37.6%, p = 0.008; and 33.6% vs. 25.5%, p = 0.001, respectively), whereas blood group B was less frequent (15.1% vs. 25.0%, p = 0.003). Multivariate analysis indicated that blood groups A (AOR = 2.43, 95% CI: 1.57–3.76, p < 0.001) and O (AOR = 2.26, 95% CI: 1.42–3.59, p < 0.001) were independent risk factors, while blood group B showed a protective effect (AOR = 0.61, 95% CI: 0.38–0.98, p = 0.041). These findings suggest that blood groups A and O blood groups may be associated with urolithiasis susceptibility in this population, though the underlying mechanisms require further investigation.