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Background <p>Deep dermal burns are common injuries characterized by prolonged healing time. The wound healing process involves inflammatory, proliferative, and remodeling phases regulated by growth factors, including FGF2 and EGF, which play roles in angiogenesis, fibroblast proliferation, re-epithelialization, and tissue repair. UC-MSC secretome contains cytokines and growth factors that may enhance wound healing. This pilot study aims to evaluate the effect of topical UC-MSC secretome on serum FGF2 and EGF levels and wound healing in deep dermal burns in Wistar rats.</p> Methods <p>This study used a post-test control group design in Wistar rats with deep dermal burns. Animals were divided into secretome-treated, vaseline-treated, and untreated groups, with evaluations on days 3 and 14. Serum FGF2 and EGF levels were measured using ELISA, while wound healing was assessed through wound width analysis and histopathology.</p> Results <p>Trends in serum FGF2 and EGF levels increased in all groups, with the secretome-treated group showing higer mean levels. Histopathology demonstrated better epidermal and dermal regeneration and higher healing scores in the secretome group. Clinical assessment also showed greater reduction in wound width.</p> Conclusions <p>Topical UC-MSC secretome was possibly associated with increased serum FGF2 and EGF levels and improved wound healing in deep dermal burns in Wistar rats.&#xa0;Level of Evidence: not ratable.</p>

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The effect of umbilical cord MSCs secretome on FGF2 and EGF serum levels in wound healing process of deep dermal burns in Wistar rats: a pilot study

  • 期刊论文

  • 发表日期：

    2026年7月21日

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  • Ratna Rayeni Natasha,
  • Andi Asadul Islam,
  • Fonny Josh,
  • Irfan Idris,
  • Yixin Zhang,
  • Muhammad Nasrum Massi,
  • Sachraswaty Rachman Laidding,
  • Ilhamjaya Patellongi

摘要

Background

Deep dermal burns are common injuries characterized by prolonged healing time. The wound healing process involves inflammatory, proliferative, and remodeling phases regulated by growth factors, including FGF2 and EGF, which play roles in angiogenesis, fibroblast proliferation, re-epithelialization, and tissue repair. UC-MSC secretome contains cytokines and growth factors that may enhance wound healing. This pilot study aims to evaluate the effect of topical UC-MSC secretome on serum FGF2 and EGF levels and wound healing in deep dermal burns in Wistar rats.

Methods

This study used a post-test control group design in Wistar rats with deep dermal burns. Animals were divided into secretome-treated, vaseline-treated, and untreated groups, with evaluations on days 3 and 14. Serum FGF2 and EGF levels were measured using ELISA, while wound healing was assessed through wound width analysis and histopathology.

Results

Trends in serum FGF2 and EGF levels increased in all groups, with the secretome-treated group showing higer mean levels. Histopathology demonstrated better epidermal and dermal regeneration and higher healing scores in the secretome group. Clinical assessment also showed greater reduction in wound width.

Conclusions

Topical UC-MSC secretome was possibly associated with increased serum FGF2 and EGF levels and improved wound healing in deep dermal burns in Wistar rats. Level of Evidence: not ratable.