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Background <p>Female pattern hair loss (FPHL) is characterized by progressive follicular miniaturization and vertex thinning. Although topical minoxidil is first-line therapy, response may be limited by inconsistent follicular delivery. Needle-free intradermal delivery may improve local delivery while minimizing invasiveness. This study evaluated the short-term efficacy and tolerability of needle-free intradermal minoxidil delivery combined with standard topical therapy in women with early FPHL.</p> Methods <p>In this study, 40 women with Ludwig stage I–II FPHL were included in the final analysis. Participants received either topical minoxidil alone or topical minoxidil with weekly needle-free intradermal delivery for 10 weeks. Outcomes included vertex hair count, hair shaft diameter, GAIS, patient satisfaction, and safety.</p> Results <p>Both groups showed improvement at Week 10. A greater proportion of participants in the combination group achieved a ≥ 10-hair increase, with rates of 75.0% (15/20) and 40.0% (8/20), respectively (<i>p</i> = 0.025). Mean hair shaft diameter increased by 4.1 ± 2.6&#xa0;μm and 2.3 ± 2.4&#xa0;μm, respectively; the between-group difference was 1.8&#xa0;μm (95% CI, 0.20–3.40; <i>p</i> = 0.029). GAIS favored the combination group. No serious adverse events were observed.</p> Conclusions <p>In this observational study, needle-free intradermal minoxidil delivery combined with standard topical therapy was associated with improved early hair growth parameters and acceptable tolerability in women with early FPHL. As an adjunct to standard topical therapy, this approach may represent a feasible strategy to support early treatment response; however, longer-term and randomized studies are needed to confirm durability and clinical effectiveness.</p> Level of evidence <p>Level III, therapeutic study.</p>

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Needle-free jet delivery of minoxidil in early female pattern hair loss: an observational comparative study in Asian women

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Kyu-Ho Yi,
  • Yerin Park,
  • Isaac Kai Jie Wong,
  • Jong Keun Song,
  • Dagne Pupo Ricardo,
  • Chang-Il Yoon,
  • Kyu-Eun Lee

摘要

Background

Female pattern hair loss (FPHL) is characterized by progressive follicular miniaturization and vertex thinning. Although topical minoxidil is first-line therapy, response may be limited by inconsistent follicular delivery. Needle-free intradermal delivery may improve local delivery while minimizing invasiveness. This study evaluated the short-term efficacy and tolerability of needle-free intradermal minoxidil delivery combined with standard topical therapy in women with early FPHL.

Methods

In this study, 40 women with Ludwig stage I–II FPHL were included in the final analysis. Participants received either topical minoxidil alone or topical minoxidil with weekly needle-free intradermal delivery for 10 weeks. Outcomes included vertex hair count, hair shaft diameter, GAIS, patient satisfaction, and safety.

Results

Both groups showed improvement at Week 10. A greater proportion of participants in the combination group achieved a ≥ 10-hair increase, with rates of 75.0% (15/20) and 40.0% (8/20), respectively (p = 0.025). Mean hair shaft diameter increased by 4.1 ± 2.6 μm and 2.3 ± 2.4 μm, respectively; the between-group difference was 1.8 μm (95% CI, 0.20–3.40; p = 0.029). GAIS favored the combination group. No serious adverse events were observed.

Conclusions

In this observational study, needle-free intradermal minoxidil delivery combined with standard topical therapy was associated with improved early hair growth parameters and acceptable tolerability in women with early FPHL. As an adjunct to standard topical therapy, this approach may represent a feasible strategy to support early treatment response; however, longer-term and randomized studies are needed to confirm durability and clinical effectiveness.

Level of evidence

Level III, therapeutic study.