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Background <p>Various extracellular matrix–based biomaterials are used in tissue regeneration; however, challenges remain regarding their applicability, including rejection and production difficulties. The ovine forestomach matrix (OFM) has demonstrated low immunogenicity and high regenerative capacity, aiding wound healing. These properties are related to its production process, which involves decellularization and removal of immunogenic components. As a result, healthcare professionals have applied OFM in different clinical contexts, ranging from wound healing to fistula treatment. This study aimed to analyze the use of OFM in the treatment of human wounds.</p> Methods <p>An integrative descriptive review with a systematic literature search was conducted in PubMed, Embase, Cochrane Library, Web of Science, Scopus, and Elsevier. The search strategy included the terms “ovine forestomach matrix,” “wound,” “wounds,” and “healing.” Studies involving human subjects that reported clinical outcomes related to wound treatment were included. The methodological quality of the studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. The study selection process followed PRISMA recommendations.</p> Results <p>A total of 75 records were identified. After removal of review articles and eligibility screening, 20 studies were included in the final analysis, comprising 1,787 patients and 2,449 wounds. Most studies were case reports or case series, resulting in moderate overall methodological quality. Reported outcomes suggested that OFM may promote granulation tissue formation, support epithelialization, and contribute to wound closure across a variety of clinical scenarios. Mean wound closure time across studies reporting this outcome was approximately 18.4 weeks, although substantial heterogeneity in study design, wound etiology, and outcome reporting was observed.</p> Conclusions <p>Available evidence suggests that OFM is a promising biomaterial for the management of complex wounds, with potential benefits including accelerated healing and relatively low cost compared with other extracellular matrix products. However, the predominance of observational studies and heterogeneity in reported outcomes highlight the need for well-designed prospective studies and randomized controlled trials to better define its clinical effectiveness. Level of evidence: not gradable.</p>

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Ovine forestomach matrix for wound treatment: an integrative review

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Marcos Fortes,
  • João Moreira,
  • Ana Carolina Fernandes,
  • Débora Wilbert

摘要

Background

Various extracellular matrix–based biomaterials are used in tissue regeneration; however, challenges remain regarding their applicability, including rejection and production difficulties. The ovine forestomach matrix (OFM) has demonstrated low immunogenicity and high regenerative capacity, aiding wound healing. These properties are related to its production process, which involves decellularization and removal of immunogenic components. As a result, healthcare professionals have applied OFM in different clinical contexts, ranging from wound healing to fistula treatment. This study aimed to analyze the use of OFM in the treatment of human wounds.

Methods

An integrative descriptive review with a systematic literature search was conducted in PubMed, Embase, Cochrane Library, Web of Science, Scopus, and Elsevier. The search strategy included the terms “ovine forestomach matrix,” “wound,” “wounds,” and “healing.” Studies involving human subjects that reported clinical outcomes related to wound treatment were included. The methodological quality of the studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. The study selection process followed PRISMA recommendations.

Results

A total of 75 records were identified. After removal of review articles and eligibility screening, 20 studies were included in the final analysis, comprising 1,787 patients and 2,449 wounds. Most studies were case reports or case series, resulting in moderate overall methodological quality. Reported outcomes suggested that OFM may promote granulation tissue formation, support epithelialization, and contribute to wound closure across a variety of clinical scenarios. Mean wound closure time across studies reporting this outcome was approximately 18.4 weeks, although substantial heterogeneity in study design, wound etiology, and outcome reporting was observed.

Conclusions

Available evidence suggests that OFM is a promising biomaterial for the management of complex wounds, with potential benefits including accelerated healing and relatively low cost compared with other extracellular matrix products. However, the predominance of observational studies and heterogeneity in reported outcomes highlight the need for well-designed prospective studies and randomized controlled trials to better define its clinical effectiveness. Level of evidence: not gradable.