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Background <p>“Prejuvenation,” the early initiation of aesthetic procedures before visible signs of aging, has emerged as a prominent trend fuelled by social media marketing and practitioner endorsement. While promoted as preventive care, its scientific foundation and long-term benefits remain unproven. This study critically examines the clinical legitimacy, digital propagation, and ethical implications of prejuvenation.</p> Methods <p>We conducted a multi-modal analysis integrating global survey data (<i>n</i> = 15,320), large-scale social media discourse (14.98&#xa0;million posts), psycholinguistic mapping, and predictive modelling. Posts from TikTok, Instagram, X, VK, Reddit, and YouTube were classified by author type and analyzed for sentiment, promotional tone, and scientific citation presence using a fine-tuned BERT model. Topic modelling (LDA) and statistical analyses, including Chi-square tests, MANOVA, logistic regression, and Bayesian hierarchical modelling, assessed content patterns, generational trends, and predictors of treatment intent.</p> Results <p>60% of prejuvenation-related content originated from credentialed professionals or clinic marketers, with promotional language prevalent across all groups (68% among physicians; 95% among lay influencers). Only 12% of practitioner-authored posts adhered to evidence-based communication standards. High-Persuasive Appeal Score (PAS ≥ 8) content generated up to 6.2 times more engagement than high-Scientific Validation Index (SVI ≥ 8) content. Dominant psychological drivers included fear of aging (31%), peer conformity (26%), and body image anxiety (6%), disproportionately affecting women aged 18–24. Consumer surveys revealed scepticism toward early intervention, citing ethical and financial concerns.</p> Conclusions <p>Prejuvenation, as currently practiced, reflects a commercially driven construct rather than an evidence-based medical advance. The dominance of persuasive but scientifically weak narratives—particularly targeting younger demographics—raises ethical concerns and underscores the need for regulatory guidelines. Aesthetic medicine must reorient toward evidence-based preventive care to preserve clinical integrity. Level of Evidence: Not ratable.</p>

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Prejuvenation in aesthetic dermatology: market-driven innovation or science-detached illusion?

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Eqram Rahman,
  • Alain Michon,
  • Parinitha Rao,
  • Patricia Garcia,
  • Mobasheratul Jannat,
  • Sotirios Ioannidis,
  • Jean Carruthers,
  • William Richard Webb

摘要

Background

“Prejuvenation,” the early initiation of aesthetic procedures before visible signs of aging, has emerged as a prominent trend fuelled by social media marketing and practitioner endorsement. While promoted as preventive care, its scientific foundation and long-term benefits remain unproven. This study critically examines the clinical legitimacy, digital propagation, and ethical implications of prejuvenation.

Methods

We conducted a multi-modal analysis integrating global survey data (n = 15,320), large-scale social media discourse (14.98 million posts), psycholinguistic mapping, and predictive modelling. Posts from TikTok, Instagram, X, VK, Reddit, and YouTube were classified by author type and analyzed for sentiment, promotional tone, and scientific citation presence using a fine-tuned BERT model. Topic modelling (LDA) and statistical analyses, including Chi-square tests, MANOVA, logistic regression, and Bayesian hierarchical modelling, assessed content patterns, generational trends, and predictors of treatment intent.

Results

60% of prejuvenation-related content originated from credentialed professionals or clinic marketers, with promotional language prevalent across all groups (68% among physicians; 95% among lay influencers). Only 12% of practitioner-authored posts adhered to evidence-based communication standards. High-Persuasive Appeal Score (PAS ≥ 8) content generated up to 6.2 times more engagement than high-Scientific Validation Index (SVI ≥ 8) content. Dominant psychological drivers included fear of aging (31%), peer conformity (26%), and body image anxiety (6%), disproportionately affecting women aged 18–24. Consumer surveys revealed scepticism toward early intervention, citing ethical and financial concerns.

Conclusions

Prejuvenation, as currently practiced, reflects a commercially driven construct rather than an evidence-based medical advance. The dominance of persuasive but scientifically weak narratives—particularly targeting younger demographics—raises ethical concerns and underscores the need for regulatory guidelines. Aesthetic medicine must reorient toward evidence-based preventive care to preserve clinical integrity. Level of Evidence: Not ratable.