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Background <p>Intraoperative bleeding and postoperative periorbital ecchymosis are common concerns in rhinoplasty, often leading to delayed post-operative recovery. This meta-analysis aimed to evaluate the effectiveness of injectable agents in controlling intraoperative bleeding and preventing ecchymosis.</p> Methods <p>A systematic search of randomized controlled trials (RCTs) was conducted across multiple databases, including Cochrane, MEDLINE, and EMBASE, following the PRISMA guidelines. Studies evaluating injectables for minimizing intraoperative bleeding and postoperative ecchymosis in rhinoplasty were included.</p> Results <p>A meta-analysis of 6 Randomized controlled trials including 514 patients undergoing surgical rhinoplasty under 4 different interventions aimed to control intraoperative bleeding. However, Tranexamic acid (TXA) demonstrated significant superiority in reducing intraoperative bleeding compared to adrenaline 14.70 [3.05; 26.36], and control 13.85 [7.54; 20.16].</p> Conclusions <p>The meta-analysis confirmed that TXA is the most effective injectable agent for controlling intraoperative bleeding and reducing postoperative ecchymosis in rhinoplasty patients. This finding highlights the importance of incorporating TXA in rhinoplasty procedures to improve surgical outcomes and patient recovery.</p> <p>Level of Evidence: Level I, therapeutic study.</p>

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Injectables in preventing intraoperative bleeding and postoperative ecchymosis in surgical rhinoplasty: a systematic review and network meta-analysis

  • 期刊论文

  • 发表日期：

    2025年2月5日

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  • Nawaf Alhindi,
  • Ghadeer Mohammed Alhassan,
  • Razan Alshuaibi,
  • Noorain Asif Hamdani,
  • Ahmed Aldhahri,
  • Zainab Alnahwi,
  • Ameera Alkhamesi,
  • Hajar Alrashed,
  • Talal A. Albalawi

摘要

Background

Intraoperative bleeding and postoperative periorbital ecchymosis are common concerns in rhinoplasty, often leading to delayed post-operative recovery. This meta-analysis aimed to evaluate the effectiveness of injectable agents in controlling intraoperative bleeding and preventing ecchymosis.

Methods

A systematic search of randomized controlled trials (RCTs) was conducted across multiple databases, including Cochrane, MEDLINE, and EMBASE, following the PRISMA guidelines. Studies evaluating injectables for minimizing intraoperative bleeding and postoperative ecchymosis in rhinoplasty were included.

Results

A meta-analysis of 6 Randomized controlled trials including 514 patients undergoing surgical rhinoplasty under 4 different interventions aimed to control intraoperative bleeding. However, Tranexamic acid (TXA) demonstrated significant superiority in reducing intraoperative bleeding compared to adrenaline 14.70 [3.05; 26.36], and control 13.85 [7.54; 20.16].

Conclusions

The meta-analysis confirmed that TXA is the most effective injectable agent for controlling intraoperative bleeding and reducing postoperative ecchymosis in rhinoplasty patients. This finding highlights the importance of incorporating TXA in rhinoplasty procedures to improve surgical outcomes and patient recovery.

Level of Evidence: Level I, therapeutic study.