Scholarlink

Background <p>Emerging evidence suggests that patent foramen ovale (PFO) contributes to the pathophysiology of migraine without aura, but related neuroimaging evidence remains scarce. In this study, we aimed to investigate changes in baseline brain activity in resting-state functional magnetic resonance imaging (rs-fMRI) between migraine without aura patients with PFO (MP) and those without PFO (MnP).</p> Methods <p>We enrolled 30 patients with MP, 30 patients with MnP, and 30 healthy controls (HCs). All participants underwent psychological testing and rs-fMRI scans. Amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and secondary seed-based voxel-wise functional connectivity (FC) were used to explore brain network abnormalities. Group differences were tested using voxel-wise covariance analysis. Partial correlation analyses were then performed to assess the clinical relevance of abnormal functional indices.</p> Results <p>Compared to HCs and MnPs, MPs showed altered ALFF in the right precentral and postcentral gyri, as well as changes in ReHo in the bilateral inferior and middle temporal gyri. Seed-based FC analysis revealed that the right inferior and middle temporal gyri showed altered FC with the right superior temporal gyrus, supramarginal gyrus, and angular gyrus; whereas the right precentral and postcentral gyri showed FC changes with the left precentral gyrus, postcentral gyrus, left supramarginal gyrus, and inferior parietal lobule. Notably, ALFF in the right precentral and postcentral gyri in the MP group was positively correlated with migraine attack frequency.</p> Conclusions <p>These findings may be related to PFO characteristics in patients with MP and provide further insights into the neuropathophysiology of migraine and PFO comorbidities.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Abnormal baseline brain activity in migraine without aura with versus without patent foramen ovale: a resting-state functional magnetic resonance imaging study

  • 期刊论文

  • 发表日期：

    2026年2月21日

查看全文
  • Chenyu Dai,
  • Yixuan Hu,
  • Mei Huang,
  • Xiaoqing Liu,
  • Zi Tao,
  • Xiaojie Zhang,
  • Xinhao Li,
  • Xi Yang,
  • Mengqian Ye,
  • Fangwang Fu,
  • Yungang Cao,
  • Yan Li,
  • Keyang Chen,
  • Beilei Hu,
  • Xiaozheng Liu

摘要

Background

Emerging evidence suggests that patent foramen ovale (PFO) contributes to the pathophysiology of migraine without aura, but related neuroimaging evidence remains scarce. In this study, we aimed to investigate changes in baseline brain activity in resting-state functional magnetic resonance imaging (rs-fMRI) between migraine without aura patients with PFO (MP) and those without PFO (MnP).

Methods

We enrolled 30 patients with MP, 30 patients with MnP, and 30 healthy controls (HCs). All participants underwent psychological testing and rs-fMRI scans. Amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and secondary seed-based voxel-wise functional connectivity (FC) were used to explore brain network abnormalities. Group differences were tested using voxel-wise covariance analysis. Partial correlation analyses were then performed to assess the clinical relevance of abnormal functional indices.

Results

Compared to HCs and MnPs, MPs showed altered ALFF in the right precentral and postcentral gyri, as well as changes in ReHo in the bilateral inferior and middle temporal gyri. Seed-based FC analysis revealed that the right inferior and middle temporal gyri showed altered FC with the right superior temporal gyrus, supramarginal gyrus, and angular gyrus; whereas the right precentral and postcentral gyri showed FC changes with the left precentral gyrus, postcentral gyrus, left supramarginal gyrus, and inferior parietal lobule. Notably, ALFF in the right precentral and postcentral gyri in the MP group was positively correlated with migraine attack frequency.

Conclusions

These findings may be related to PFO characteristics in patients with MP and provide further insights into the neuropathophysiology of migraine and PFO comorbidities.