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Background and purpose <p>Stent-assisted coiling has revolutionized the treatment of wide-neck intracranial aneurysms. Several technical improvements have since emerged, including enhanced deliverability, low-profile designs, and reduced surface thrombogenicity. This study aimed to assess the real-world feasibility, safety, and efficacy of the pEGASUS-HPC device for intracranial aneurysms.</p> Materials and methods <p>This independent, multicenter, retrospective observational study evaluated patients treated with pEGASUS-HPC stent-assisted coiling between April 2022 and December 2024. Data on procedural outcomes, complications (technical and clinical), and imaging follow-up were analyzed.</p> Results <p>Ninety-nine aneurysms (30 ruptured (30.3%), 69 unruptured (69.7%)) in 98 patients (58 female (59.2%), 40 male (40.8%) were treated using 130 pEGASUS-HPC stents. The successful deployment rate was 97%. Device-related mortality and morbidity were 2% and 1%, respectively. Ischemic complication rates did not significantly differ between acute and elective cases or between single and dual antiplatelet therapy groups. Adequate occlusion (Raymond-Roy Class I–II) was achieved in 95% immediately post-procedure and 93% at follow-up (median 240 days).</p> Conclusions <p>The pEGASUS-HPC stent shows high feasibility, safety, and effectiveness in the treatment of intracranial aneurysms. Further research is warranted to assess the impact of its surface coating, especially in emergency settings.</p>

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Real-world use of the pEGASUS-HPC stent in cerebral aneurysms: results from a multicenter retrospective series

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • Lozupone Emilio,
  • Roland Barbante,
  • Giovanni Barchetti,
  • Mikel Terceño Izaga,
  • Victor Vazquez-Añón,
  • Sandra Bracco,
  • Nicola Limbucci,
  • Luigi Cirillo,
  • Panagiotis Paraschakis,
  • Vittorio Semeraro,
  • Isabel Rodríguez Caamaño,
  • Flavio Giordano,
  • Alfredo Pauciulo,
  • Adriana Paladini

摘要

Background and purpose

Stent-assisted coiling has revolutionized the treatment of wide-neck intracranial aneurysms. Several technical improvements have since emerged, including enhanced deliverability, low-profile designs, and reduced surface thrombogenicity. This study aimed to assess the real-world feasibility, safety, and efficacy of the pEGASUS-HPC device for intracranial aneurysms.

Materials and methods

This independent, multicenter, retrospective observational study evaluated patients treated with pEGASUS-HPC stent-assisted coiling between April 2022 and December 2024. Data on procedural outcomes, complications (technical and clinical), and imaging follow-up were analyzed.

Results

Ninety-nine aneurysms (30 ruptured (30.3%), 69 unruptured (69.7%)) in 98 patients (58 female (59.2%), 40 male (40.8%) were treated using 130 pEGASUS-HPC stents. The successful deployment rate was 97%. Device-related mortality and morbidity were 2% and 1%, respectively. Ischemic complication rates did not significantly differ between acute and elective cases or between single and dual antiplatelet therapy groups. Adequate occlusion (Raymond-Roy Class I–II) was achieved in 95% immediately post-procedure and 93% at follow-up (median 240 days).

Conclusions

The pEGASUS-HPC stent shows high feasibility, safety, and effectiveness in the treatment of intracranial aneurysms. Further research is warranted to assess the impact of its surface coating, especially in emergency settings.