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Purpose <p> This study investigated glymphatic function in tremor disorders using the diffusion tensor imaging–derived ALPS (analysis-along-the-perivascular-space) index, a non-invasive surrogate of perivascular fluid movement.</p> Materials and Methods <p> Fourty-three patients with tremor-dominant Parkinson’s disease (PD, n=22) or essential tremor (ET, n=21), aged 50–75, were retrospectively compared with 18 age-matched healthy controls (HC) imaged with the same 3 T MRI protocol. Subjects with significant cognitive impairment, white matter disease, other CNS disorders, or poor-quality diffusion data were excluded. ALPS indices were calculated from projection and association fibre regions.</p> Results <p>Both PD (mean ALPS = 1.34 ± 0.19) and ET ( 1.31 ± 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54±0.11 P &lt; 0.05), but no difference was 13 found between PD and ET.</p> <p> In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R²=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (ρ=0.462, p=0.018).&#xa0;</p> Conclusion <p> The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.</p>

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Similar DTI-ALPS metrics in Parkinson’s disease and essential tremor: a cross-sectional comparative analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月20日

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  • Federico Bruno,
  • Antonio Innocenzi,
  • Pierfrancesco Badini,
  • Marco Cella,
  • Chiara Santobuono,
  • Leonardo Pertici,
  • Alessia Catalucci,
  • Gennaro Saporito,
  • Patrizia Sucapane,
  • Pierpaolo Palumbo,
  • Francesco Arrigoni,
  • Antonio Barile,
  • Ernesto Di Cesare,
  • Francesca Pistoia,
  • Alessandra Splendiani

摘要

Purpose

This study investigated glymphatic function in tremor disorders using the diffusion tensor imaging–derived ALPS (analysis-along-the-perivascular-space) index, a non-invasive surrogate of perivascular fluid movement.

Materials and Methods

Fourty-three patients with tremor-dominant Parkinson’s disease (PD, n=22) or essential tremor (ET, n=21), aged 50–75, were retrospectively compared with 18 age-matched healthy controls (HC) imaged with the same 3 T MRI protocol. Subjects with significant cognitive impairment, white matter disease, other CNS disorders, or poor-quality diffusion data were excluded. ALPS indices were calculated from projection and association fibre regions.

Results

Both PD (mean ALPS = 1.34 ± 0.19) and ET ( 1.31 ± 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54±0.11 P < 0.05), but no difference was 13 found between PD and ET.

In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R²=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (ρ=0.462, p=0.018). 

Conclusion

The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.