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Purpose <p>Breath-hold functional MRI (bh-fMRI) is able to quantify cerebrovascular reactivity. Vessel stenoses can lead to delayed hemodynamic responses. We aimed to investigate whether delay correction improves the quality of bh-fMRI compared to the diagnostic standard [<sup>15</sup>O]water PET.</p> Methods <p>The bh-fMRI data sets of 25 patients with Moyamoya Angiopathy were analyzed retrospectively without and with delay correction. Delay correction was calculated using time-to-peak (TTP) maps derived from dynamic susceptibility contrast (DSC) perfusion MRI. [<sup>15</sup>O]water PET maps and bh-fMRI maps without and with delay correction were presented blinded for delay correction to two neuroradiologists. The agreement between bh-fMRI without and with delay correction and [<sup>15</sup>O]water PET was independently and consensually rated on a 4-point-Likert scale (1 = poor, 2 = moderate, 3 = good, 4 = excellent) and compared with Wilcoxon signed-rank test.</p> Results <p>The agreement between bh-fMRI and [<sup>15</sup>O]water PET without delay correction was good/excellent (median = 3, modus = 4), and improved significantly after delay correction with medium effect size (median = 4, modus = 4, z = -2.121, <i>p</i> = 0.034, <i>r</i> = 0.42).</p> Conclusion <p>Delay correction improves the quality of bh-fMRI and seems to be helpful in clinical practice.</p>

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Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [15O]water PET

  • 期刊论文

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  • 发表日期：

    2025年5月24日

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  • Leonie Zerweck,
  • Uwe Klose,
  • Constantin Roder,
  • Deborah Staber,
  • Emely Renger,
  • Ganna Blazhenets,
  • Kathrin Grundmann-Hauser,
  • Philipp T. Meyer,
  • Ulrike Ernemann,
  • Till-Karsten Hauser

摘要

Purpose

Breath-hold functional MRI (bh-fMRI) is able to quantify cerebrovascular reactivity. Vessel stenoses can lead to delayed hemodynamic responses. We aimed to investigate whether delay correction improves the quality of bh-fMRI compared to the diagnostic standard [15O]water PET.

Methods

The bh-fMRI data sets of 25 patients with Moyamoya Angiopathy were analyzed retrospectively without and with delay correction. Delay correction was calculated using time-to-peak (TTP) maps derived from dynamic susceptibility contrast (DSC) perfusion MRI. [15O]water PET maps and bh-fMRI maps without and with delay correction were presented blinded for delay correction to two neuroradiologists. The agreement between bh-fMRI without and with delay correction and [15O]water PET was independently and consensually rated on a 4-point-Likert scale (1 = poor, 2 = moderate, 3 = good, 4 = excellent) and compared with Wilcoxon signed-rank test.

Results

The agreement between bh-fMRI and [15O]water PET without delay correction was good/excellent (median = 3, modus = 4), and improved significantly after delay correction with medium effect size (median = 4, modus = 4, z = -2.121, p = 0.034, r = 0.42).

Conclusion

Delay correction improves the quality of bh-fMRI and seems to be helpful in clinical practice.