Let $X$ be a smooth, complex Fano 4-fold, and $\rho _{X}$ its Picard number. We show that if $\rho _{X}>12$ , then $X$ is a product of del Pezzo surfaces. The proof relies on a careful study of divisorial elementary contractions $f\colon X\to Y$ such that $\dim f(\operatorname{Exc}(f))=2$ , together with the author’s previous work on Fano 4-folds. In particular, given $f\colon X\to Y$ as above, under suitable assumptions we show that $S:=f(\operatorname{Exc}(f))$ is a smooth del Pezzo surface with $-K_{S}=(-K_{Y})_{|S}$ .