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<p>Trigeminal neuralgia (TN) is characterized by intense and recurrent episodes of pain in the orofacial region, mainly affecting the second (V2) and third (V3) divisions of the trigeminal nerve. Recent studies suggest that TN may be associated with structural alterations in the limbic system, particularly the amygdala, a core region for the emotion-related network, involved in emotional aspects of pain and pain modulation. This study evaluated the volumetry of the amygdala and its nine nuclei in patients with TN compared to healthy controls. Structural Magnetic Resonance Imaging (MRI) data were analyzed from 111 TN patients and 48 healthy volunteers. MRI scans were acquired using a 3&#xa0;T MRI scanner with high-resolution 3D T1w sequences (2022–2024) at the Federal Neurosurgical Center in Novosibirsk, Russia, and assessed via the OpenNeuro database. Amygdala volumetry was performed using FreeSurfer software. Morphometric analysis revealed significantly lower volumes of both the left (<i>p</i> = 0.02, η<sup>2</sup>p = 0.13) and the right amygdala (<i>p</i> = 0.005, η<sup>2</sup>p = 0.05) in TN patients, compared to healthy controls. Additionally, TN patients exhibited smaller bilateral volumes in the cortical nucleus of the amygdala as well as smaller volumes of the medial, accessory basal, and corticoamygdaloid transition nuclei of the right amygdala, when compared to the control group. Amygdala alterations may reflect impaired pain modulation in trigeminal neuralgia (TN), affecting sensory and affective aspects of pain.</p>

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Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Lucas Rego Ramos,
  • Tamires Morett Gama,
  • Ana Clara de Mendonça Maia,
  • Luiza Helena da Fonseca Lima,
  • Orlando Fernandes Jr,
  • Paulo Henrique Rosado de Castro,
  • Marcos Fabio DosSantos

摘要

Trigeminal neuralgia (TN) is characterized by intense and recurrent episodes of pain in the orofacial region, mainly affecting the second (V2) and third (V3) divisions of the trigeminal nerve. Recent studies suggest that TN may be associated with structural alterations in the limbic system, particularly the amygdala, a core region for the emotion-related network, involved in emotional aspects of pain and pain modulation. This study evaluated the volumetry of the amygdala and its nine nuclei in patients with TN compared to healthy controls. Structural Magnetic Resonance Imaging (MRI) data were analyzed from 111 TN patients and 48 healthy volunteers. MRI scans were acquired using a 3 T MRI scanner with high-resolution 3D T1w sequences (2022–2024) at the Federal Neurosurgical Center in Novosibirsk, Russia, and assessed via the OpenNeuro database. Amygdala volumetry was performed using FreeSurfer software. Morphometric analysis revealed significantly lower volumes of both the left (p = 0.02, η2p = 0.13) and the right amygdala (p = 0.005, η2p = 0.05) in TN patients, compared to healthy controls. Additionally, TN patients exhibited smaller bilateral volumes in the cortical nucleus of the amygdala as well as smaller volumes of the medial, accessory basal, and corticoamygdaloid transition nuclei of the right amygdala, when compared to the control group. Amygdala alterations may reflect impaired pain modulation in trigeminal neuralgia (TN), affecting sensory and affective aspects of pain.