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<p><i>Agrocybe aegerita</i> (<i>A. aegerita</i>), a globally cultivated mushroom, is increasingly recognized as a functional food owing to its rich profile of bioactive compounds and diverse health benefits. This review evaluates its composition and bioactivities. Predominant macronutrients are carbohydrates (84.50&#xa0;g/100&#xa0;g DW) and proteins (6.68&#xa0;g/100&#xa0;g DW), alongside essential trace elements and unsaturated fatty acids (PUFAs, 78.60%). Key bioactives include polysaccharides (β-glucans), lectins (AAL), antioxidant peptides, phenolics, tocopherols, and the ribotoxin ageritin. These compounds contribute to significant biological activities: polysaccharides and phenolics exert potent antioxidant effects, extending lifespan in <i>D. melanogaster</i> and <i>C. elegans</i>. Ageritin and lectins demonstrate dose-dependent, pro-apoptotic antitumor activity against glioblastoma and other cancers. Extracts also exhibit anti-inflammatory (via COX inhibition), antimicrobial (including anti-biofilm), antiviral (e.g., Hepatitis B suppression), immunomodulatory, prebiotic, and potential antidiabetic properties. However, challenges remain in standardization, molecular research, and clinical validation. Given its unique nutritional profile and demonstrated bioactivities, <i>A. aegerita</i> holds significant potential for development into novel nutraceuticals and functional food products aimed at health promotion and disease risk reduction.</p>

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Agrocybe aegerita as a functional food: chemical composition and biological activities

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Shuai Zong,
  • Hongyi Liu,
  • Jing Zhang,
  • Song Ming,
  • Tiantian Huang,
  • Yuguang Du,
  • Jun Liu

摘要

Agrocybe aegerita (A. aegerita), a globally cultivated mushroom, is increasingly recognized as a functional food owing to its rich profile of bioactive compounds and diverse health benefits. This review evaluates its composition and bioactivities. Predominant macronutrients are carbohydrates (84.50 g/100 g DW) and proteins (6.68 g/100 g DW), alongside essential trace elements and unsaturated fatty acids (PUFAs, 78.60%). Key bioactives include polysaccharides (β-glucans), lectins (AAL), antioxidant peptides, phenolics, tocopherols, and the ribotoxin ageritin. These compounds contribute to significant biological activities: polysaccharides and phenolics exert potent antioxidant effects, extending lifespan in D. melanogaster and C. elegans. Ageritin and lectins demonstrate dose-dependent, pro-apoptotic antitumor activity against glioblastoma and other cancers. Extracts also exhibit anti-inflammatory (via COX inhibition), antimicrobial (including anti-biofilm), antiviral (e.g., Hepatitis B suppression), immunomodulatory, prebiotic, and potential antidiabetic properties. However, challenges remain in standardization, molecular research, and clinical validation. Given its unique nutritional profile and demonstrated bioactivities, A. aegerita holds significant potential for development into novel nutraceuticals and functional food products aimed at health promotion and disease risk reduction.