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<p>Many studies have reported that procyanidins can improve type 2 diabetes mellitus (T2DM), but the differential efficacy between A-type and B-type procyanidins has not been systematically compared, limiting the development of structure-specific therapies. This study investigated the antidiabetic effects of lotus seed skin procyanidins (LSP) and peanut skin procyanidins (PSP), which were identified by HPLC-Orbitrap-MS analysis to be rich in B-type and A-type procyanidins, respectively. In vitro assays indicated that PSP showed stronger inhibitory activity against α-amylase and α-glucosidase than LSP. In diabetic mice, both LSP and PSP significantly alleviated hyperphagia, polydipsia, dyslipidemia, hepatic steatosis, and oxidative stress. Notably, PSP more effectively improved glucose tolerance, fasting blood glucose (FBG), and hepatic histopathology than LSP. These findings highlight A-type procyanidins as potent multi-target antidiabetic agents, acting through digestive enzyme inhibition, lipid content regulation, and oxidative stress mitigation.</p>

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Composition analysis and comparative antidiabetic evaluation of procyanidins from Lotus seed skins and peanut skins

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Siyi Zhou,
  • Xiang Li,
  • Jiaolong Li,
  • Zhiyan Zhu,
  • Lingping He,
  • Si Qin,
  • Fangfang Yan

摘要

Many studies have reported that procyanidins can improve type 2 diabetes mellitus (T2DM), but the differential efficacy between A-type and B-type procyanidins has not been systematically compared, limiting the development of structure-specific therapies. This study investigated the antidiabetic effects of lotus seed skin procyanidins (LSP) and peanut skin procyanidins (PSP), which were identified by HPLC-Orbitrap-MS analysis to be rich in B-type and A-type procyanidins, respectively. In vitro assays indicated that PSP showed stronger inhibitory activity against α-amylase and α-glucosidase than LSP. In diabetic mice, both LSP and PSP significantly alleviated hyperphagia, polydipsia, dyslipidemia, hepatic steatosis, and oxidative stress. Notably, PSP more effectively improved glucose tolerance, fasting blood glucose (FBG), and hepatic histopathology than LSP. These findings highlight A-type procyanidins as potent multi-target antidiabetic agents, acting through digestive enzyme inhibition, lipid content regulation, and oxidative stress mitigation.