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<p>Green coconut water is a widely consumed natural beverage known for its nutritional benefits and traditional medicinal applications. Recent studies have identified three antimicrobial peptides (AMPs) in coconut water: <b>Cn-AMP1</b>, <b>Cn-AMP2</b>, and <b>Cn-AMP3</b>. They were demonstrated to exhibit broad-spectrum antimicrobial activity against bacteria and fungi, as well as anticancer properties. Among them, <b>Cn-AMP1</b> stands out as the most potent compound, showing significantly lower cytotoxicity than many conventional drugs and other AMPs. Hence, these findings highlight the potential of these coconut peptides as potent multifunctional agents that could revolutionize how we approach food safety, nutrition, and therapeutic interventions. Nonetheless, their moderate efficacy and susceptibility to enzymatic degradation necessitate structural modifications and innovative delivery strategies to enhance therapeutic potential. This review explores the structural characteristics, biological activities, and future prospects of coconut AMPs, emphasizing their role in functional food and therapeutic applications.</p> Graphic abstract <p></p>

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Antimicrobial peptides in green coconut water: from nutritional benefits to multifunctional applications for human health

  • 期刊论文

  • 发表日期：

    2025年5月3日

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  • Hoa Doan Ngan,
  • Binh Le Huy,
  • Chi Le Uyen,
  • Hai Bui Thi Phuong,
  • Huy Luong Xuan

摘要

Green coconut water is a widely consumed natural beverage known for its nutritional benefits and traditional medicinal applications. Recent studies have identified three antimicrobial peptides (AMPs) in coconut water: Cn-AMP1, Cn-AMP2, and Cn-AMP3. They were demonstrated to exhibit broad-spectrum antimicrobial activity against bacteria and fungi, as well as anticancer properties. Among them, Cn-AMP1 stands out as the most potent compound, showing significantly lower cytotoxicity than many conventional drugs and other AMPs. Hence, these findings highlight the potential of these coconut peptides as potent multifunctional agents that could revolutionize how we approach food safety, nutrition, and therapeutic interventions. Nonetheless, their moderate efficacy and susceptibility to enzymatic degradation necessitate structural modifications and innovative delivery strategies to enhance therapeutic potential. This review explores the structural characteristics, biological activities, and future prospects of coconut AMPs, emphasizing their role in functional food and therapeutic applications.

Graphic abstract