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<p>In this study, we presented the design and development of a flexible and non-enzymatic electrochemical sensor based on in situ growth of Au nanowires (AuNWs) on carbon cloth (CC) for the dynamic monitoring of uric acid levels in human sweat. The electrode was fabricated through a controllable process, resulting in a three-dimensional conductive network with high surface area and abundant electroactive sites on the electrode surface. Electrochemical analyses demonstrated that the electrode exhibits excellent sensitivity toward uric acid with a wide linear response range from 10 to 700&#xa0;μM and a low detection limit of 1.4&#xa0;μM. The electrode was further integrated into a wearable sensing platform and applied for real-time, non-invasive sweat sampling and monitoring during exercise. The results indicated that the sensor exhibited a high correlation between sweat and blood uric acid levels measured by a commercial device, validating its potential applicability for the daily monitoring of uric acid. This work provides a promising strategy for the development of facile and reliable wearable sensors, with significant potential in non-invasive healthcare monitoring.</p> Graphical abstract <p>A flexible and wearable sensor by in situ growth of Au nanowires on carbon cloth was developed for the real-time and non-invasive monitoring of uric acid metabolite in sweat.</p> <p></p>

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In situ growth of Au nanowires based wearable sensor for real-time monitoring of uric acid metabolite in sweat

  • 期刊论文

  • 发表日期：

    2026年2月19日

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  • Zhengyuan Ding,
  • Linlian Zhu,
  • Yaqiu Zhou,
  • Mengwei Li,
  • Yi Yao,
  • Mengjie Su,
  • Zengqiang Wu,
  • Li Wang,
  • Chunmei Yu

摘要

In this study, we presented the design and development of a flexible and non-enzymatic electrochemical sensor based on in situ growth of Au nanowires (AuNWs) on carbon cloth (CC) for the dynamic monitoring of uric acid levels in human sweat. The electrode was fabricated through a controllable process, resulting in a three-dimensional conductive network with high surface area and abundant electroactive sites on the electrode surface. Electrochemical analyses demonstrated that the electrode exhibits excellent sensitivity toward uric acid with a wide linear response range from 10 to 700 μM and a low detection limit of 1.4 μM. The electrode was further integrated into a wearable sensing platform and applied for real-time, non-invasive sweat sampling and monitoring during exercise. The results indicated that the sensor exhibited a high correlation between sweat and blood uric acid levels measured by a commercial device, validating its potential applicability for the daily monitoring of uric acid. This work provides a promising strategy for the development of facile and reliable wearable sensors, with significant potential in non-invasive healthcare monitoring.

Graphical abstract

A flexible and wearable sensor by in situ growth of Au nanowires on carbon cloth was developed for the real-time and non-invasive monitoring of uric acid metabolite in sweat.