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<p>A novel coupling of a miniaturized thermal desorption chip (TDC) with a flexible microtube plasma (FµTP) ionization source and ion mobility spectrometry (IMS) enables direct, solvent-free analysis of a&#xa0;liquid sample. The integrated TDC-FµTP-IMS system combines sample introduction, preconcentration, and time-resolved desorption via adjustable temperature gradients. Quantitative analysis of a ketone mixture demonstrated excellent linearity and detection limits between 34 µg L<sup>−1</sup> and 79 µg L<sup>−1</sup>. In addition, <i>N</i>-hexanoyl homoserine lactone was successfully quantified from a liquid sample without manual preparation. The method provides a fast, sensitive, and selective approach for direct liquid-phase IMS applications.</p> Graphical abstract <p></p>

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Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月28日

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  • Annika Fechner,
  • Carolin Drees,
  • Wolfgang Vautz,
  • Stefanie Sielemann,
  • Ursula Telgheder,
  • Joachim Franzke,
  • Sebastian Brandt

摘要

A novel coupling of a miniaturized thermal desorption chip (TDC) with a flexible microtube plasma (FµTP) ionization source and ion mobility spectrometry (IMS) enables direct, solvent-free analysis of a liquid sample. The integrated TDC-FµTP-IMS system combines sample introduction, preconcentration, and time-resolved desorption via adjustable temperature gradients. Quantitative analysis of a ketone mixture demonstrated excellent linearity and detection limits between 34 µg L−1 and 79 µg L−1. In addition, N-hexanoyl homoserine lactone was successfully quantified from a liquid sample without manual preparation. The method provides a fast, sensitive, and selective approach for direct liquid-phase IMS applications.

Graphical abstract