Scholarlink

<p>Environmental health concerns over per- and polyfluoroalkyl substances (PFAS) have prompted public health laboratories to pursue monitoring studies determining PFAS occurrences. Select laboratories have begun implementing non-targeted analysis (NTA) methods to address the disparity between the few (&lt; 100) PFAS typically measured using targeted analyses and the thousands of known PFAS. While NTA can provide a more comprehensive understanding of PFAS occurrence, significant barriers prevent its widespread adoption in public health laboratories. Notable barriers include a lack of harmonized guidance, standardized methods, and workflows that enable robust NTA application. EPA’s Office of Research and Development has been working to overcome these barriers as part of technical collaborations with state environmental and public health laboratories. As a product of these efforts, ORD has developed the ENTAiLS Toolkit, a publicly available compilation of best practices and an open-source data processing workflow for PFAS NTA studies. The ENTAiLS Toolkit offers NTA practitioners comprehensive guidance and integrated tools that can aid the identification and characterization of PFAS in drinking water resources.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The ENTAiLS Toolkit: an integrated workflow to perform non-targeted analysis of per- and polyfluoroalkyl substances

  • 期刊论文

  • 发表日期：

    2025年6月5日

查看全文
  • Heather D. Whitehead,
  • Timothy J. Buckley,
  • Jon R. Sobus,
  • Jacqueline Bangma,
  • Denise K. MacMillan,
  • Troy M. Ferland,
  • Alex Chao,
  • Antony J. Williams,
  • Gregory Janesch,
  • Regina Poeske,
  • Erin Newman,
  • Carole Braverman,
  • Matthew Small,
  • Sinisa Urban,
  • Zhao Cao,
  • Andri Dahlmeier,
  • Stefan Saravia,
  • Rosie Rushing,
  • Marla DeVault,
  • Wendy Linck,
  • Erica Kalve,
  • David Schiessel,
  • James P. McCord

摘要

Environmental health concerns over per- and polyfluoroalkyl substances (PFAS) have prompted public health laboratories to pursue monitoring studies determining PFAS occurrences. Select laboratories have begun implementing non-targeted analysis (NTA) methods to address the disparity between the few (< 100) PFAS typically measured using targeted analyses and the thousands of known PFAS. While NTA can provide a more comprehensive understanding of PFAS occurrence, significant barriers prevent its widespread adoption in public health laboratories. Notable barriers include a lack of harmonized guidance, standardized methods, and workflows that enable robust NTA application. EPA’s Office of Research and Development has been working to overcome these barriers as part of technical collaborations with state environmental and public health laboratories. As a product of these efforts, ORD has developed the ENTAiLS Toolkit, a publicly available compilation of best practices and an open-source data processing workflow for PFAS NTA studies. The ENTAiLS Toolkit offers NTA practitioners comprehensive guidance and integrated tools that can aid the identification and characterization of PFAS in drinking water resources.

Graphical abstract