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<p>Early diagnosis of cancer is a major concern in clinical medicine.&#xa0;Recently, aptamer-based microfluidics have offered promising platforms for the sensitive detection of cancer biomarkers.&#xa0;This review summarizes the application of aptamer sensors in the microfluidic platform for cancer biomarker analysis. The materials for microfluidic aptamer biosensor fabrication, unique design based on microposts, materials for enhanced detection capability, and the application principle of combining with other detection methods are introduced in detail, so as to demonstrate its development potential in cancer diagnosis and personalized therapy. Finally, the challenges and opportunities for developing miniaturized diagnostic platforms are discussed.</p>

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Aptamer-based microfluidics for the detection of cancer biomarkers

  • 期刊论文

  • 发表日期：

    2025年4月14日

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  • Yi-Xin-Yue Gong,
  • Xiao-Feng Huang,
  • Jian Liang,
  • Jing Xie,
  • Lin-Sen Qing

摘要

Early diagnosis of cancer is a major concern in clinical medicine. Recently, aptamer-based microfluidics have offered promising platforms for the sensitive detection of cancer biomarkers. This review summarizes the application of aptamer sensors in the microfluidic platform for cancer biomarker analysis. The materials for microfluidic aptamer biosensor fabrication, unique design based on microposts, materials for enhanced detection capability, and the application principle of combining with other detection methods are introduced in detail, so as to demonstrate its development potential in cancer diagnosis and personalized therapy. Finally, the challenges and opportunities for developing miniaturized diagnostic platforms are discussed.