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Rationale <p>Acute alcohol intoxication impairs cognitive and motor control, elevating risk in safety–critical contexts. While blood alcohol concentration (BAC) quantifies exposure, it does not reflect real-time functional impairment. Mobile, performance-based assessments may offer scalable detection tools, but their sensitivity under controlled alcohol challenge requires further validation.</p> Objectives <p>To evaluate the sensitivity of a mobile cognitive assessment (DRUID®) to alcohol-induced impairment across low and moderate intoxication levels and examined objective cognitive performance and subjective intoxication within a unified framework.</p> Methods <p>In a randomised, double-blind, placebo-controlled, within-subjects trial, 30 healthy adults (33% female; aged 23–49&#xa0;years) completed neurocognitive testing following placebo, low-dose alcohol (mean peak BAC 0.04%), and moderate-dose alcohol (mean peak BAC 0.07%). Cognitive performance was measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and DRUID®, while subjective effects were assessed via the Brief Biphasic Alcohol Effects Scale and a single-item intoxication rating.</p> Results <p>Moderate alcohol intoxication significantly impaired spatial working memory, sustained attention, and psychomotor control (all <i>p</i> &lt; 0.05), and elevated DRUID® impairment scores at 130&#xa0;min post-dose relative to placebo (<i>p</i> &lt; 0.001). Low-dose alcohol increased subjective intoxication and sedation (both <i>p</i> &lt; 0.001) without measurable cognitive impairment.</p> Conclusions <p>Moderate alcohol produced persistent neurocognitive deficits despite dissociation between subjective and objective measures. Findings support performance-based impairment models and highlight mobile cognitive tools such as DRUID® as practical candidates for real-time functional assessment in applied safety settings.</p> Trial registration <p>ACTRN12623000528651, 19/05/2023.</p>

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A randomised, double-blind, placebo-controlled trial examining the dose-dependent effects of acute alcohol intoxication on neurocognitive performance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月14日

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  • Blair Aitken,
  • Brook Shiferaw,
  • Luke A. Downey,
  • Brooke Manning,
  • Thomas Arkell,
  • Michael G. Lenné,
  • Jonny Kuo,
  • Amie C. Hayley

摘要

Rationale

Acute alcohol intoxication impairs cognitive and motor control, elevating risk in safety–critical contexts. While blood alcohol concentration (BAC) quantifies exposure, it does not reflect real-time functional impairment. Mobile, performance-based assessments may offer scalable detection tools, but their sensitivity under controlled alcohol challenge requires further validation.

Objectives

To evaluate the sensitivity of a mobile cognitive assessment (DRUID®) to alcohol-induced impairment across low and moderate intoxication levels and examined objective cognitive performance and subjective intoxication within a unified framework.

Methods

In a randomised, double-blind, placebo-controlled, within-subjects trial, 30 healthy adults (33% female; aged 23–49 years) completed neurocognitive testing following placebo, low-dose alcohol (mean peak BAC 0.04%), and moderate-dose alcohol (mean peak BAC 0.07%). Cognitive performance was measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and DRUID®, while subjective effects were assessed via the Brief Biphasic Alcohol Effects Scale and a single-item intoxication rating.

Results

Moderate alcohol intoxication significantly impaired spatial working memory, sustained attention, and psychomotor control (all p < 0.05), and elevated DRUID® impairment scores at 130 min post-dose relative to placebo (p < 0.001). Low-dose alcohol increased subjective intoxication and sedation (both p < 0.001) without measurable cognitive impairment.

Conclusions

Moderate alcohol produced persistent neurocognitive deficits despite dissociation between subjective and objective measures. Findings support performance-based impairment models and highlight mobile cognitive tools such as DRUID® as practical candidates for real-time functional assessment in applied safety settings.

Trial registration

ACTRN12623000528651, 19/05/2023.