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Rationale <p>Postpartum estrous (PPE) rats are able to care for their litter and copulate with a male, however when given the choice, they prefer their pups over males. This preference is stronger in multiparous rats than in primiparous rats, indicating that previous reproductive experience increases their maternal motivation. Dopaminergic neurotransmission, particularly that acting on D1-like receptors in the Nucleus Accumbens (NAcc) and the medial Preoptic Area (mPOA), has been implicated in controlling maternal motivation and maternal behavior execution.</p> Objective <p>Determining whether the dopaminergic system differs between primiparous and multiparous PPE rats.</p> Methods <p>Two approaches were employed: 1) determining the effect of systemic administration of the selective D1-like receptors antagonist SCH-23390 (at 0.0, 0.025, and 0.05&#xa0;mg/kg doses) on maternal behavior execution and locomotion, and 2) determining D1- and D2-like receptors binding in the NAcc, dorsal striatum, medial prefrontal cortex, and mPOA of primiparous and multiparous PPE rats.</p> Results <p>SCH-23390 reduced the active components of maternal behavior and locomotor activity in PPE rats, with the lower dose of this D1-like receptors antagonist having greater effects in multiparous females. Compared to primiparous females, multiparous rats also exhibited increased binding to the D1-like receptors antagonist [<sup>3</sup>H]-SCH-23390 in NAcc and dorsal striatum and reduced binding to the D2-like receptors antagonist [<sup>3</sup>H]-nemonapride in the NAcc shell.</p> Conclusions <p>These findings demonstrate that prior reproductive experience alters the behavioral sensitivity to SCH-23390 and its binding in the striatum of PPE rats.</p>

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Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Marin G.,
  • Bedó G.,
  • Uriarte N.,
  • Antonelli M.C.,
  • Ferreira A.,
  • Agrati D.

摘要

Rationale

Postpartum estrous (PPE) rats are able to care for their litter and copulate with a male, however when given the choice, they prefer their pups over males. This preference is stronger in multiparous rats than in primiparous rats, indicating that previous reproductive experience increases their maternal motivation. Dopaminergic neurotransmission, particularly that acting on D1-like receptors in the Nucleus Accumbens (NAcc) and the medial Preoptic Area (mPOA), has been implicated in controlling maternal motivation and maternal behavior execution.

Objective

Determining whether the dopaminergic system differs between primiparous and multiparous PPE rats.

Methods

Two approaches were employed: 1) determining the effect of systemic administration of the selective D1-like receptors antagonist SCH-23390 (at 0.0, 0.025, and 0.05 mg/kg doses) on maternal behavior execution and locomotion, and 2) determining D1- and D2-like receptors binding in the NAcc, dorsal striatum, medial prefrontal cortex, and mPOA of primiparous and multiparous PPE rats.

Results

SCH-23390 reduced the active components of maternal behavior and locomotor activity in PPE rats, with the lower dose of this D1-like receptors antagonist having greater effects in multiparous females. Compared to primiparous females, multiparous rats also exhibited increased binding to the D1-like receptors antagonist [3H]-SCH-23390 in NAcc and dorsal striatum and reduced binding to the D2-like receptors antagonist [3H]-nemonapride in the NAcc shell.

Conclusions

These findings demonstrate that prior reproductive experience alters the behavioral sensitivity to SCH-23390 and its binding in the striatum of PPE rats.