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Introduction <p>There is an exponential increase in the number of patients seeking treatment, including inpatient detoxification, for cocaine use disorder. We propose to test the ability of the MoCA test, a simple screening tool for cognitive dysfunction, administered in early abstinence, to predict relapse. We also aimed at describing the factors associated with the MoCA score.</p> Methods <p>We conducted a prospective study where 58 patients were assessed in the first 72&#xa0;h after entering an inpatient cocaine cessation program. Relapse was determined prospectively up to three months after discharge. We conducted a univariate analysis and an exploratory logistic regression to predict relapse, as well as a univariate and linear regression to identify factors associated with the MoCA score. </p> Results <p>We observed that patients who relapsed during the follow-up (<i>N</i> = 51) had significantly lower initial mean MoCA scores than abstainers (<i>N</i> = 7) (<i>p</i> = 0.037). In the logistic regression, a low MoCA score was not retained as a significant independent predictor of relapse (β=-0.293; <i>p</i> = 0.089). In the linear regression model with the MoCA score as the dependent variable, crack-cocaine use (<i>versus</i> cocaine hydrochloride) (β=-0.427; <i>p</i> &lt; 0.001) and a lower educational level ((β = 0.301; <i>p</i> = 0.014) were independently associated with low MOCA score. The crash MoCA score could be tested in future studies assessing its ability to measure the early cognitive cocaine withdrawal symptoms.</p>

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Does the cognitive test MoCA at entry of an inpatient cocaine cessation predict relapse? a prospective observational study

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Victor Caillet,
  • Margot Chouchana,
  • Margaux Poireau,
  • Virgile Clergue-Duval,
  • Julien Azuar,
  • Romain Icick,
  • Angéline Maillard,
  • Emmanuelle Volle,
  • Christine Delmaire,
  • Vanessa Bloch,
  • Florence Vorspan

摘要

Introduction

There is an exponential increase in the number of patients seeking treatment, including inpatient detoxification, for cocaine use disorder. We propose to test the ability of the MoCA test, a simple screening tool for cognitive dysfunction, administered in early abstinence, to predict relapse. We also aimed at describing the factors associated with the MoCA score.

Methods

We conducted a prospective study where 58 patients were assessed in the first 72 h after entering an inpatient cocaine cessation program. Relapse was determined prospectively up to three months after discharge. We conducted a univariate analysis and an exploratory logistic regression to predict relapse, as well as a univariate and linear regression to identify factors associated with the MoCA score.

Results

We observed that patients who relapsed during the follow-up (N = 51) had significantly lower initial mean MoCA scores than abstainers (N = 7) (p = 0.037). In the logistic regression, a low MoCA score was not retained as a significant independent predictor of relapse (β=-0.293; p = 0.089). In the linear regression model with the MoCA score as the dependent variable, crack-cocaine use (versus cocaine hydrochloride) (β=-0.427; p < 0.001) and a lower educational level ((β = 0.301; p = 0.014) were independently associated with low MOCA score. The crash MoCA score could be tested in future studies assessing its ability to measure the early cognitive cocaine withdrawal symptoms.