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Rationale <p>Preclinical and clinical findings support the potential for GLP-1 receptor activation to reduce alcohol consumption and reward. Human experimental studies are needed to clarify whether acute changes in endogenous GLP-1 influence alcohol craving and responses to alcohol. Dietary stimulation may present a method to study the effects of endogenous GLP-1 on responses to alcohol.</p> Objectives <p>Assess the effects of a dietary manipulation on acute changes in GLP-1 and laboratory responses to alcohol.</p> Methods <p>Healthy young adult heavy drinkers (<i>N</i> = 40) were recruited to participate in two study visits where they received a dietary supplement designed to increase endogenous GLP-1 or a calorically matched placebo in counterbalanced order. Blood was sampled before and 40&#xa0;min after supplement or placebo administration to measure changes in plasma GLP-1. Subjective effects, craving, and alcohol attentional bias were measured in response to a priming drink of alcohol (target BAC 30&#xa0;mg%).</p> Results <p>Compared to placebo, dietary supplement preload significantly increased blood GLP-1 concentration, <i>β</i> = 0.79, <i>p</i> &lt; 0.001, and significantly reduced alcohol attentional bias, <i>β</i> = -0.56, <i>p</i> = 0.010. Blood GLP-1 concentration correlated with the magnitude of alcohol attentional bias reduction after supplement preload (<i>r</i> = -0.30). There were no significant effects of the manipulation on subjective responses or craving.</p> Conclusions <p>Results suggest that dietary stimulation may reduce the incentive motivational properties of alcohol-related cues, potentially through increases in endogenous GLP-1, absent effects on self-report measures of alcohol subjective response or craving. Acute changes in circulating GLP-1 may influence implicit motivation for alcohol.</p>

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Effect of dietary stimulation on acute changes in GLP-1, alcohol responses, craving, and attentional bias: a randomized, placebo-controlled laboratory study

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Michael P. Bremmer,
  • Jimikaye B. Courtney,
  • Andrew P. Neilson,
  • Kyle S. Burger,
  • Todd E. Thiele,
  • Christian S. Hendershot

摘要

Rationale

Preclinical and clinical findings support the potential for GLP-1 receptor activation to reduce alcohol consumption and reward. Human experimental studies are needed to clarify whether acute changes in endogenous GLP-1 influence alcohol craving and responses to alcohol. Dietary stimulation may present a method to study the effects of endogenous GLP-1 on responses to alcohol.

Objectives

Assess the effects of a dietary manipulation on acute changes in GLP-1 and laboratory responses to alcohol.

Methods

Healthy young adult heavy drinkers (N = 40) were recruited to participate in two study visits where they received a dietary supplement designed to increase endogenous GLP-1 or a calorically matched placebo in counterbalanced order. Blood was sampled before and 40 min after supplement or placebo administration to measure changes in plasma GLP-1. Subjective effects, craving, and alcohol attentional bias were measured in response to a priming drink of alcohol (target BAC 30 mg%).

Results

Compared to placebo, dietary supplement preload significantly increased blood GLP-1 concentration, β = 0.79, p < 0.001, and significantly reduced alcohol attentional bias, β = -0.56, p = 0.010. Blood GLP-1 concentration correlated with the magnitude of alcohol attentional bias reduction after supplement preload (r = -0.30). There were no significant effects of the manipulation on subjective responses or craving.

Conclusions

Results suggest that dietary stimulation may reduce the incentive motivational properties of alcohol-related cues, potentially through increases in endogenous GLP-1, absent effects on self-report measures of alcohol subjective response or craving. Acute changes in circulating GLP-1 may influence implicit motivation for alcohol.