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Objective <p>This study investigates the role of AMPK-mediated mitochondrial function in mediating electroacupuncture (EA) antidepressant effects in a post-stroke depression (PSD) rat model.</p> Methods <p>Electroacupuncture was administered to PSD rats for 16 consecutive days, after which behavioral performance, oxidative stress parameters, inflammation-related markers, AMPK pathway components, and cerebrospinal fluid ATP concentrations were compared between the experimental and control groups.</p> Results <p>Electroacupuncture ameliorated cerebral ischemia and diminished the size of cerebral infarction. Furthermore, PSD-induced depressive-like behaviors were prevented by EA therapy. EA also reduced neuronal death and oxidative stress injury in PSD rats. Additionally, EA treatment markedly reduced inflammatory markers. Notably, electroacupuncture upregulated the expression of AMPK and elevated the concentration of ATP.</p> Conclusion <p>These findings provide compelling evidence that electroacupuncture activating the AMPK pathway to mitigate mitochondrial oxidative stress, thereby alleviating inflammation and preventing excessive ATP degradation to exerts antidepressant effects.</p>

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Electroacupuncture alleviates depressive symptoms in post-stroke depression rat models by AMPK-mediated mitochondrial pathway

  • 期刊论文

  • 发表日期：

    2026年2月13日

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  • Jiang He,
  • Donghui Yang,
  • Ying Ye,
  • Xianfen Zhu

摘要

Objective

This study investigates the role of AMPK-mediated mitochondrial function in mediating electroacupuncture (EA) antidepressant effects in a post-stroke depression (PSD) rat model.

Methods

Electroacupuncture was administered to PSD rats for 16 consecutive days, after which behavioral performance, oxidative stress parameters, inflammation-related markers, AMPK pathway components, and cerebrospinal fluid ATP concentrations were compared between the experimental and control groups.

Results

Electroacupuncture ameliorated cerebral ischemia and diminished the size of cerebral infarction. Furthermore, PSD-induced depressive-like behaviors were prevented by EA therapy. EA also reduced neuronal death and oxidative stress injury in PSD rats. Additionally, EA treatment markedly reduced inflammatory markers. Notably, electroacupuncture upregulated the expression of AMPK and elevated the concentration of ATP.

Conclusion

These findings provide compelling evidence that electroacupuncture activating the AMPK pathway to mitigate mitochondrial oxidative stress, thereby alleviating inflammation and preventing excessive ATP degradation to exerts antidepressant effects.