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Background <p>Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most studies of cannabis used fixed laboratory doses which may not capture some of the nuances of more naturalistic doses. Delta-9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis yet the relationship of blood THC to cognitive performance is unclear.</p> Methods <p>In the present observational study participants (<i>n</i> = 22) were invited to the lab to use their regular legally sourced cannabis edibles. At 150 and 270&#xa0;min after ingesting the edible, measures of learning and memory (verbal free recall task), executive function (trail making test) and functional vision and visual attention (useful field of view test) were taken. Subjective experiences were also measured, and blood THC was correlated with cognitive outcomes.</p> Results <p>At 150&#xa0;min after taking a cannabis edible (mean 7.3 ± 2.9&#xa0;mg of delta-9-tetrahydrocannabinol) decreases were seen in performance on two measures of the verbal free recall. No effects were found on the useful field of view and trail making tests. There were significant increases in subjective experiences as assessed with a visual analog scale and the Addiction Research Centre Inventory; some changes were also seen on the Profile of Mood States. Blood THC was not correlated with any cognitive outcomes.</p> Conclusions <p>In sum, the present results suggest that people who choose to use relatively low doses of cannabis edibles may experience decrements in cognitive function while experiencing intoxication.</p>

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Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Patricia Di Ciano,
  • Sampson Zhao,
  • Pamela Kaduri,
  • Siddhi Patel,
  • Kruti Bhakta,
  • Christine M. Wickens,
  • Sheng Chen,
  • Bernard Le Foll,
  • Bruna Brands

摘要

Background

Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most studies of cannabis used fixed laboratory doses which may not capture some of the nuances of more naturalistic doses. Delta-9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis yet the relationship of blood THC to cognitive performance is unclear.

Methods

In the present observational study participants (n = 22) were invited to the lab to use their regular legally sourced cannabis edibles. At 150 and 270 min after ingesting the edible, measures of learning and memory (verbal free recall task), executive function (trail making test) and functional vision and visual attention (useful field of view test) were taken. Subjective experiences were also measured, and blood THC was correlated with cognitive outcomes.

Results

At 150 min after taking a cannabis edible (mean 7.3 ± 2.9 mg of delta-9-tetrahydrocannabinol) decreases were seen in performance on two measures of the verbal free recall. No effects were found on the useful field of view and trail making tests. There were significant increases in subjective experiences as assessed with a visual analog scale and the Addiction Research Centre Inventory; some changes were also seen on the Profile of Mood States. Blood THC was not correlated with any cognitive outcomes.

Conclusions

In sum, the present results suggest that people who choose to use relatively low doses of cannabis edibles may experience decrements in cognitive function while experiencing intoxication.