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Rationale <p>Low socioeconomic status people make up a majority of those who use cannabis during pregnancy. Both developmental cannabis exposure and developmental stress increase the risk of developing psychiatric disorders; however, the interaction of these factors has not been studied.</p> Objectives <p>This study examined whether prenatal and early postnatal cannabis exposure (PPCE) impacted susceptibility to chronic adolescent stress in a dose- and environment-controlled animal model.</p> Methods <p>Mouse dams orally consumed 5&#xa0;mg/kg THC in whole cannabis oil daily from GD1-PD10. Offspring were exposed to chronic mild unpredictable stress throughout adolescence (PD28-56). From PD58, mice were challenged with a battery of tests to measure anxiety-like (elevated plus maze, open field test), stress coping (forced swim test, tail suspension test), anhedonia-like (sucrose preference), risk-taking behaviour (wire beam bridge), and social motivation (3 chamber sociability and social novelty task). Brain slices were taken 90&#xa0;min after forced swim test to analyze c-Fos expression.</p> Results <p>PPCE did not interact with chronic adolescent stress to impact anxiety-like, acute stress coping, or social motivation. However, co-exposed mice showed a significantly increased incidence of bridge crossing in the wire beam bridge task, whereas stress-only exposed animals did not. There were sex differences in c-FOS expression in the prefrontal cortex (PFC) in response to stress and PPCE.</p> Conclusions <p>These data indicate that PPCE, when combined with adolescent stress, increases risk-taking behaviour.</p>

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Prenatal and early postnatal cannabis exposure interactions with adolescent chronic stress on anxiety-like, depression-like, and risk-taking behaviour

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月29日

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  • Colleen S. Peterson,
  • Ijeoma Ifionu,
  • Fatima Hamood,
  • Hadi Semizeh,
  • Ahmad Ali,
  • Duncan Noble,
  • Min Qiao,
  • Stephanie L. Borgland

摘要

Rationale

Low socioeconomic status people make up a majority of those who use cannabis during pregnancy. Both developmental cannabis exposure and developmental stress increase the risk of developing psychiatric disorders; however, the interaction of these factors has not been studied.

Objectives

This study examined whether prenatal and early postnatal cannabis exposure (PPCE) impacted susceptibility to chronic adolescent stress in a dose- and environment-controlled animal model.

Methods

Mouse dams orally consumed 5 mg/kg THC in whole cannabis oil daily from GD1-PD10. Offspring were exposed to chronic mild unpredictable stress throughout adolescence (PD28-56). From PD58, mice were challenged with a battery of tests to measure anxiety-like (elevated plus maze, open field test), stress coping (forced swim test, tail suspension test), anhedonia-like (sucrose preference), risk-taking behaviour (wire beam bridge), and social motivation (3 chamber sociability and social novelty task). Brain slices were taken 90 min after forced swim test to analyze c-Fos expression.

Results

PPCE did not interact with chronic adolescent stress to impact anxiety-like, acute stress coping, or social motivation. However, co-exposed mice showed a significantly increased incidence of bridge crossing in the wire beam bridge task, whereas stress-only exposed animals did not. There were sex differences in c-FOS expression in the prefrontal cortex (PFC) in response to stress and PPCE.

Conclusions

These data indicate that PPCE, when combined with adolescent stress, increases risk-taking behaviour.