Scholarlink

<p>Reproductive injury is a core pathological process leading to gamete dysfunction, gonadal structural damage, and impaired reproductive capacity. Basic research has revealed that its pathogenesis involves a complex regulatory network of oxidative stress, inflammatory response, germ cell apoptosis, hypothalamic-pituitary–gonadal (HPG) axis disorder, mitochondrial dysfunction, and epigenetic dysregulation. <i>Panax ginseng</i> C. A. Meyer, a classic medicinal and edible herb, and its bioactive constituents have shown reproductive protective effects in numerous <i>in vitro</i> and <i>in vivo</i> basic studies. This review systematically summarizes the core pathological mechanisms of reproductive injury revealed by basic research, sorts out the main bioactive constituents of ginseng and their remarkable functional characteristics in reproductive protection, focuses on the potent molecular mechanisms and basic research progress of ginseng and its active ingredients against reproductive injury, and identifies the limitations of current basic research and future research directions. This review aims to provide a systematic theoretical basis for further basic research of ginseng in the field of reproductive protection, and to support the in-depth exploration of its intervention mechanism and active ingredient development.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective effects of ginseng against reproductive injury: mechanisms and research progress

  • 期刊论文

  • 发表日期：

    2026年8月1日

查看全文
  • Chao Jiang,
  • Wei Li,
  • Ying-ping Wang

摘要

Reproductive injury is a core pathological process leading to gamete dysfunction, gonadal structural damage, and impaired reproductive capacity. Basic research has revealed that its pathogenesis involves a complex regulatory network of oxidative stress, inflammatory response, germ cell apoptosis, hypothalamic-pituitary–gonadal (HPG) axis disorder, mitochondrial dysfunction, and epigenetic dysregulation. Panax ginseng C. A. Meyer, a classic medicinal and edible herb, and its bioactive constituents have shown reproductive protective effects in numerous in vitro and in vivo basic studies. This review systematically summarizes the core pathological mechanisms of reproductive injury revealed by basic research, sorts out the main bioactive constituents of ginseng and their remarkable functional characteristics in reproductive protection, focuses on the potent molecular mechanisms and basic research progress of ginseng and its active ingredients against reproductive injury, and identifies the limitations of current basic research and future research directions. This review aims to provide a systematic theoretical basis for further basic research of ginseng in the field of reproductive protection, and to support the in-depth exploration of its intervention mechanism and active ingredient development.