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<p>Chemoresistance in hepatocellular carcinoma (HCC) complicates treatment and poses a substantial and growing burden to healthcare systems worldwide. Despite remarkable advances in recent years, the massive volume of publications has made it hard to identify overarching trends, critical turning points, and emerging frontiers. The present study aimed to conduct a comprehensive analysis of the global research landscape and summarize future hotspots. Articles on chemoresistance in HCC published in the Science Citation Index Expanded, Web of Science Core Collection, from 1991 to 2025 were searched. Bibliometrix (R package) was used for data analysis and visualization. CiteSpace was employed for keywords bursts detection. A total of 2571 publications by 12243 authors from 643 sources were included. An increase in the annual growth in the number of publications and citations was observed. Cancers had the most publications, and Cancer Research was the most cited. China and the USA are the dominant countries in this field. Sun Yat Sen University is the most productive affiliation. Wang Y is the most productive author. Besides topic-relevant keywords, terms like "expression," "apoptosis, " and "metastasis,” etc. had high occurrence. Thematic shifts were also identified, transitioning from single-agent and single-target approaches to complex combination therapies and novel technological interventions. Conclusively, through a bibliometric analysis of publications, the present work shows key developments in the field of chemoresistance in HCC. Potential research hotspots include advanced combinatorial nano-immunotherapy, ferroptosis inducers, combined immunotherapy, and metabolic plasticity and stemness pathway regulators of cancer stem cells.</p>

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Global research hotspots and evolving themes in chemoresistance of hepatocellular carcinoma: a bibliometric analysis from a pharmacological perspective

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Lihua Chen,
  • Songbin Lin,
  • Zhekun Huang,
  • Yirui Yin

摘要

Chemoresistance in hepatocellular carcinoma (HCC) complicates treatment and poses a substantial and growing burden to healthcare systems worldwide. Despite remarkable advances in recent years, the massive volume of publications has made it hard to identify overarching trends, critical turning points, and emerging frontiers. The present study aimed to conduct a comprehensive analysis of the global research landscape and summarize future hotspots. Articles on chemoresistance in HCC published in the Science Citation Index Expanded, Web of Science Core Collection, from 1991 to 2025 were searched. Bibliometrix (R package) was used for data analysis and visualization. CiteSpace was employed for keywords bursts detection. A total of 2571 publications by 12243 authors from 643 sources were included. An increase in the annual growth in the number of publications and citations was observed. Cancers had the most publications, and Cancer Research was the most cited. China and the USA are the dominant countries in this field. Sun Yat Sen University is the most productive affiliation. Wang Y is the most productive author. Besides topic-relevant keywords, terms like "expression," "apoptosis, " and "metastasis,” etc. had high occurrence. Thematic shifts were also identified, transitioning from single-agent and single-target approaches to complex combination therapies and novel technological interventions. Conclusively, through a bibliometric analysis of publications, the present work shows key developments in the field of chemoresistance in HCC. Potential research hotspots include advanced combinatorial nano-immunotherapy, ferroptosis inducers, combined immunotherapy, and metabolic plasticity and stemness pathway regulators of cancer stem cells.