Scholarlink

<p>Doxorubicin (DOX), a natural compound with anticancer properties, is limited in its therapeutic application by low bioavailability and inadequate solubility. This paper presents a novel nanoparticle system designed to tackle these challenges by self-assembled DOX, polydopamine (PD) altered, and macrophage membrane (MM) coated nanoparticles (DOX-PD@MM NPs). The DOX-PD@MM NPs exhibited significant antitumor efficacy, elevated drug-loading capacity, enhanced stability, and exceptional photothermal properties. Further, the macrophage membrane endows the DOX-PD@MM NPs with active targeting to cancer tissues. We employed the U87-MG glioblastoma cell line to assess the in vitro anticancer activity of DOX-PD@MM. The findings indicate that DOX-PD@MM may efficiently induce cell death by producing reactive oxygen species (ROS) and releasing DOX. The amalgamation of DOX-PD@MM and near-infrared irradiation significantly enhanced anticancer efficacy by promoting DOX release and photothermal treatment. The DOX-PD@MM system enables drug delivery for poorly soluble drugs, thereby harnessing their full anticancer potential.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Construction of self-assembled doxorubicin-loaded polydopamine nanoparticles coated with macrophage membrane: improved photothermal/chemotherapy in glioblastoma cancer

  • 期刊论文

  • 发表日期：

    2026年4月24日

查看全文
  • Shengmou Mu,
  • Baolai Liu

摘要

Doxorubicin (DOX), a natural compound with anticancer properties, is limited in its therapeutic application by low bioavailability and inadequate solubility. This paper presents a novel nanoparticle system designed to tackle these challenges by self-assembled DOX, polydopamine (PD) altered, and macrophage membrane (MM) coated nanoparticles (DOX-PD@MM NPs). The DOX-PD@MM NPs exhibited significant antitumor efficacy, elevated drug-loading capacity, enhanced stability, and exceptional photothermal properties. Further, the macrophage membrane endows the DOX-PD@MM NPs with active targeting to cancer tissues. We employed the U87-MG glioblastoma cell line to assess the in vitro anticancer activity of DOX-PD@MM. The findings indicate that DOX-PD@MM may efficiently induce cell death by producing reactive oxygen species (ROS) and releasing DOX. The amalgamation of DOX-PD@MM and near-infrared irradiation significantly enhanced anticancer efficacy by promoting DOX release and photothermal treatment. The DOX-PD@MM system enables drug delivery for poorly soluble drugs, thereby harnessing their full anticancer potential.