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<p>Oral lichen planus (OLP), a chronic inflammatory disease affecting the stratified squamous epithelium of oral mucosa (mucositis), presents treatment challenges due to rapid washout of conventional topical gels. This study developed prednisolone acetate-loaded mucoadhesive electrospun nanofibers using PVP K90/Eudragit RS100 via Super ES-3 technology to enhance drug retention and therapeutic efficacy. Nanofibers exhibited uniform morphology (diameter ranging from185 ± 0.3&#xa0;nm to 704 ± 0.3&#xa0;nm), neutral surface pH (7.4 ± 0.1), and superior mucoadhesion of 0.03N and bond strength of 0.455 Nmm<sup>2</sup>. FTIR confirmed polymer-drug compatibility and XRD studies revealed crystalline state of drug in nanofibers. <i>In vitro</i> release from prednisolone acetate-loaded nanofibers followed zero-order kinetics (<i>r</i><sup>2</sup> = 0.999, RMSE = 1.02%, 90.21% Q₁₂ₕ), ideal for sustained delivery vis a vis. prednisolone acetate dispersion that followed Korsmeyer-Peppas model (<i>r</i><sup>2</sup> = 0.962, RMSE = 3.99, 51.34% Q<sub>12h</sub>). <i>In vivo</i> evaluations using 4% SDS-induced mucosal irritation model in Wistar rats shown irritation score of 4.333 ± 0.58 in disease control, nanofibers achieved near-complete resolution (score 1.000 ± 0.58, equivalent to vehicle <i>p</i> = 0.7538), significantly outperforming marketed formulation (3.000 ± 0.58, <i>p</i> = 0.0015; using one-way ANOVA F = 45.2, <i>p</i> &lt; 0.0001). Histopathology confirmed superiority with no signs of irritation or tissue damage of the oral mucosa showing normalized rete ridges and minimal inflammation. These findings demonstrate mucoadhesive nanofibers as a promising localized delivery system for OLP, providing sustained prednisolone acetate release, prolonged buccal retention of 7&#xa0;h, and superior therapeutic outcomes while minimizing systemic corticosteroid exposure.</p>

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Fabrication and characterization of prednisolone acetate-loaded electrospun mucoadhesive nanofibers for treatment of oral lichen planus

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Sachin,
  • Jagjit Singh Dhaliwal,
  • Amanpreet Kaur

摘要

Oral lichen planus (OLP), a chronic inflammatory disease affecting the stratified squamous epithelium of oral mucosa (mucositis), presents treatment challenges due to rapid washout of conventional topical gels. This study developed prednisolone acetate-loaded mucoadhesive electrospun nanofibers using PVP K90/Eudragit RS100 via Super ES-3 technology to enhance drug retention and therapeutic efficacy. Nanofibers exhibited uniform morphology (diameter ranging from185 ± 0.3 nm to 704 ± 0.3 nm), neutral surface pH (7.4 ± 0.1), and superior mucoadhesion of 0.03N and bond strength of 0.455 Nmm2. FTIR confirmed polymer-drug compatibility and XRD studies revealed crystalline state of drug in nanofibers. In vitro release from prednisolone acetate-loaded nanofibers followed zero-order kinetics (r2 = 0.999, RMSE = 1.02%, 90.21% Q₁₂ₕ), ideal for sustained delivery vis a vis. prednisolone acetate dispersion that followed Korsmeyer-Peppas model (r2 = 0.962, RMSE = 3.99, 51.34% Q12h). In vivo evaluations using 4% SDS-induced mucosal irritation model in Wistar rats shown irritation score of 4.333 ± 0.58 in disease control, nanofibers achieved near-complete resolution (score 1.000 ± 0.58, equivalent to vehicle p = 0.7538), significantly outperforming marketed formulation (3.000 ± 0.58, p = 0.0015; using one-way ANOVA F = 45.2, p < 0.0001). Histopathology confirmed superiority with no signs of irritation or tissue damage of the oral mucosa showing normalized rete ridges and minimal inflammation. These findings demonstrate mucoadhesive nanofibers as a promising localized delivery system for OLP, providing sustained prednisolone acetate release, prolonged buccal retention of 7 h, and superior therapeutic outcomes while minimizing systemic corticosteroid exposure.